DegronMD

Uniprot ID: Q96L73

Source protein: Histone-lysine N-methyltransferase, H3 lysine-36 specific

Source gene: NSD1

Class: DEG_APCC_KENBOX_2

Location: 794:798

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8257

ASA_SCORE: 113.14

COIL: 0.9056

CONS_SCORE: 0.3987

DSS_SCORE: 0.4274

HELIX: 0.0686

FCONS_SCORE: 1.1163

RIG_SCORE: 0.699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A801S	TCGA-AX-A2HD	UCEC	TCGA	HKENP	DEG_APCC_KENBOX_2	0.25
p.R788P	TCGA-E5-A4U1	BLCA	TCGA	HKENP	DEG_APCC_KENBOX_2	0.1667
p.R803Q	DO22237	LGG	ICGC	HKENP	DEG_APCC_KENBOX_2	0.1944
p.R785T	DO27120	LUSC	ICGC	HKENP	DEG_APCC_KENBOX_2	0.0833
p.M800I	ACH-000635	Ovarian Cancer	CCLE	HKENP	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_APCC_KENBOX_2	53:57	HKENP	APC,CDC20,FZR1	0.9957	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	794:798	HKENP	APC,CDC20,FZR1	0.8257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons