DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_APCC_KENBOX_2

Location: 53:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 119.56

COIL: 0.944

CONS_SCORE: 0.4028

DSS_SCORE: 0.6275

HELIX: 0.0194

FCONS_SCORE: 1.0994

RIG_SCORE: 0.693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R50Q	TCGA-EO-A22X	UCEC	TCGA	HKENP	DEG_APCC_KENBOX_2	0.25
p.R45Q	DO43907	UCEC	ICGC	HKENP	DEG_APCC_KENBOX_2	0.1111
p.H44Y	SIDM00789	Colorectal Carcinoma	GDSC	HKENP	DEG_APCC_KENBOX_2	0.0833
p.H44Y	SIDM00259	Neuroblastoma	GDSC	HKENP	DEG_APCC_KENBOX_2	0.0833
p.H44Y	ACH-000997	Colon/Colorectal Cancer	CCLE	HKENP	DEG_APCC_KENBOX_2	0.0833
p.H44Y	ACH-001061	Colon/Colorectal Cancer	CCLE	HKENP	DEG_APCC_KENBOX_2	0.0833
p.H44Y	ACH-002278	Neuroblastoma	CCLE	HKENP	DEG_APCC_KENBOX_2	0.0833
p.H44Y	NB10	autonomic_ganglia	COSMIC	HKENP	DEG_APCC_KENBOX_2	0.0833
p.H44Y	HCT-15	large_intestine	COSMIC	HKENP	DEG_APCC_KENBOX_2	0.0833
p.T57M	SIDM00945	Colorectal Carcinoma	GDSC	HKENP	DEG_APCC_KENBOX_2	0.7423
p.T57M	ACH-000895	Colon/Colorectal Cancer	CCLE	HKENP	DEG_APCC_KENBOX_2	0.7423
p.T57M	CL-34	large_intestine	COSMIC	HKENP	DEG_APCC_KENBOX_2	0.7423
p.T52M	CL-34	large_intestine	COSMIC	HKENP	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_APCC_KENBOX_2	53:57	HKENP	APC,CDC20,FZR1	0.9957	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	794:798	HKENP	APC,CDC20,FZR1	0.8257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons