DegronMD

Uniprot ID: Q96L73

Source protein: Histone-lysine N-methyltransferase, H3 lysine-36 specific

Source gene: NSD1

Class: DEG_SCF_FBW7_2

Location: 1254:1261

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 82.6375

COIL: 0.8445

CONS_SCORE: 0.3334

DSS_SCORE: 0.657

HELIX: 0.0931

FCONS_SCORE: 1.042

RIG_SCORE: 0.656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1270D	TCGA-AA-A010	COAD	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.0833
p.K1249N	TCGA-AP-A0LM	UCEC	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.3056
p.I1244V	TCGA-CD-A4MG	STAD	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.0556
p.P1251Q	TCGA-DA-A1IB	SKCM	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.25
p.P1263H	TCGA-EB-A24C	SKCM	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.2778
p.G1252E	TCGA-IB-7651	PAAD	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.2778
p.A1260V	TCGA-ND-A4WC	UCS	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	0.5825
p.E1251K	DO44443	HNSC	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	0.25
p.S1259Y	DO52105	HNSC	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	0.712
p.D1253Y	DO228985	LICA	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	0.3056
p.G1264C	DO229034	LICA	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	0.25
p.R1266C	DO43642	UCEC	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	0.1944
p.A1260S	SIDM00924	Other Solid Cancers	GDSC	PSLTPQAE	DEG_SCF_FBW7_2	0.6477
p.A1260S	ACH-000867	Lung Cancer	CCLE	PSLTPQAE	DEG_SCF_FBW7_2	0.6477
p.A1260S	ChaGo-K-1	lung	COSMIC	PSLTPQAE	DEG_SCF_FBW7_2	0.6477
p.G1267S	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PSLTPQAE	DEG_SCF_FBW7_2	0.1667
p.G1249C	SR	haematopoietic_and_lymphoid_tissue	COSMIC	PSLTPQAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SCF_FBW7_2	1254:1261	PSLTPQAE	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons