DegronMD

Uniprot ID: Q96L73

Source protein: Histone-lysine N-methyltransferase, H3 lysine-36 specific

Source gene: NSD1

Class: DEG_APCC_KENBOX_2

Location: 1179:1183

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8074

ASA_SCORE: 103.32

COIL: 0.4976

CONS_SCORE: 0.327

DSS_SCORE: 0.4713

HELIX: 0.4762

FCONS_SCORE: 1.0297

RIG_SCORE: 0.7008

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1185F	TCGA-17-Z016	LUAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.2778
p.C1185F	TCGA-S9-A6WG	LGG	TCGA	EKENS	DEG_APCC_KENBOX_2	0.2778
p.E1181V	TCGA-55-7994	LUAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.7693
p.R1173C	TCGA-AN-A046	BRCA	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1667
p.M1174I	TCGA-EK-A2PG	CESC	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1944
p.E1179D	TCGA-F5-6814	READ	TCGA	EKENS	DEG_APCC_KENBOX_2	0.5647
p.A1181V	DO230347	COCA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.6936
p.A1181V	DO40996	UCEC	ICGC	EKENS	DEG_APCC_KENBOX_2	0.6936
p.G1175V	DO228986	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.2222
p.E1173D	DO229026	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.G1191V	DO45321	LUAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1111
p.D1187Y	DO47769	STAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.2222
p.P1170L	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.0833
p.P1170L	ACH-002301	Lymphoma	CCLE	EKENS	DEG_APCC_KENBOX_2	0.0833
p.P1170L	RF-48	stomach	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.0833
p.R1188S	SIDM00856	Other Solid Cancers	GDSC	EKENS	DEG_APCC_KENBOX_2	0.1944
p.R1188S	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.1944
p.N1174S	DMS-53	lung	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_APCC_KENBOX_2	159:163	EKENS	APC,CDC20,FZR1	0.903	More...
Q13426	DNA repair protein XRCC4	DEG_APCC_KENBOX_2	295:299	EKENS	APC,CDC20,FZR1	0.9752	More...
Q2NKX8	DNA excision repair protein ERCC-6-like	DEG_APCC_KENBOX_2	976:980	EKENS	APC,CDC20,FZR1	0.9554	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	1179:1183	EKENS	APC,CDC20,FZR1	0.8074	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_APCC_KENBOX_2	621:625	EKENS	APC,CDC20,FZR1	0.766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons