DegronMD

Uniprot ID: Q96L73

Source protein: Histone-lysine N-methyltransferase, H3 lysine-36 specific

Source gene: NSD1

Class: DEG_COP1_1

Location: 2374:2384

E3 ligase: COP1

DEGRON score: 0.6634

ASA_SCORE: 84.5364

COIL: 0.9042

CONS_SCORE: 0.2801

DSS_SCORE: 0.729

HELIX: 0.0585

FCONS_SCORE: 0.91

RIG_SCORE: 0.6337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2377T	TCGA-06-5416	GBM	TCGA	SLEKTSVPTGL	DEG_COP1_1	0.6195
p.K2377T	SIDM01090	Colorectal Carcinoma	GDSC	SLEKTSVPTGL	DEG_COP1_1	0.6195
p.K2377T	ACH-000943	Colon/Colorectal Cancer	CCLE	SLEKTSVPTGL	DEG_COP1_1	0.6195
p.K2377T	RKO	large_intestine	COSMIC	SLEKTSVPTGL	DEG_COP1_1	0.6195
p.P2388S	TCGA-22-5479	LUSC	TCGA	SLEKTSVPTGL	DEG_COP1_1	0.2222
p.Q2373H	TCGA-AX-A2HD	UCEC	TCGA	SLEKTSVPTGL	DEG_COP1_1	0.3056
p.I2394V	TCGA-BR-4201	STAD	TCGA	SLEKTSVPTGL	DEG_COP1_1	0.0556
p.I2394V	DO38707	STAD	ICGC	SLEKTSVPTGL	DEG_COP1_1	0.0556
p.G2383C	TCGA-EE-A2GT	SKCM	TCGA	SLEKTSVPTGL	DEG_COP1_1	0.76
p.R2364W	DO219089	BLCA	ICGC	SLEKTSVPTGL	DEG_COP1_1	0.5
p.D2377N	DO52189	LIHC	ICGC	SLEKTSVPTGL	DEG_COP1_1	0.6932
p.T2382I	SIDM00267	Biliary Tract Carcinoma	GDSC	SLEKTSVPTGL	DEG_COP1_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_COP1_1	2374:2384	SLEKTSVPTGL	COP1	0.6634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons