DegronMD

Uniprot ID: O15014

Source protein: Zinc finger protein 609

Source gene: ZNF609

Class: DEG_SCF_FBW7_1

Location: 102:107

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 75.95

COIL: 0.9377

CONS_SCORE: 0.4544

DSS_SCORE: 0.7219

HELIX: 0.042

FCONS_SCORE: 1.0107

RIG_SCORE: 0.5878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P102L	TCGA-D3-A5GO	SKCM	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.6471
p.P102L	DO47419	SKCM	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.6471
p.D98Y	TCGA-DU-6392	LGG	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.2222
p.D98Y	DO22237	LGG	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.2222
p.S107F	TCGA-EE-A2MJ	SKCM	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.9093
p.S107F	DO38099	SKCM	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.9093
p.P111Q	TCGA-FS-A1ZJ	SKCM	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.2222
p.P111Q	DO37956	SKCM	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.2222
p.S95R	TCGA-ZF-A9RG	BLCA	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.5833
p.S95R	DO219076	BLCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.5833
p.L108M	DO222501	COCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.3056
p.T106I	DO234299	ESAD	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.7078
p.A115T	DO233764	GACA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1111
p.T99A	SIDM00845	Burkitt's Lymphoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.T99A	SIDM00461	Acute Myeloid Leukemia	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.T99A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.T99A	SIDM01519	Head and Neck Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.T99A	ACH-000992	Head and Neck Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	0.25
p.T99A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.T99A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.K101T	SIDM00654	Small Cell Lung Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.3056
p.K101T	SIDM01664	Prostate Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.3056
p.T110S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_SCF_FBW7_1	102:107	PTPGTS	FBXW7	0.9977	More...
Q04726	Transducin-like enhancer protein 3	DEG_SCF_FBW7_1	327:332	PTPGTS	FBXW7	0.9977	More...
Q9P202	Whirlin	DEG_SCF_FBW7_1	635:640	PTPGTS	FBXW7	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons