DegronMD

Uniprot ID: Q04726

Source protein: Transducin-like enhancer protein 3

Source gene: TLE3

Class: DEG_SCF_FBW7_1

Location: 327:332

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 69.15

COIL: 0.9393

CONS_SCORE: 0.4514

DSS_SCORE: 0.8271

HELIX: 0.0207

FCONS_SCORE: 0.9956

RIG_SCORE: 0.5465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S339L	TCGA-B7-5816	STAD	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.1389
p.S339L	TCGA-FI-A2D0	UCEC	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.1389
p.S339L	DO38599	STAD	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1389
p.S339L	DO43891	UCEC	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1389
p.P341R	TCGA-C8-A134	BRCA	TCGA	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.P341R	DO1316	BRCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.A320T	DO9788	COAD	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1389
p.A320T	DO41331	UCEC	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1389
p.L337I	DO228948	LICA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1944
p.P327T	DO228971	LICA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.7031
p.A326V	DO220854	MELA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.3056
p.P341T	DO27899	ORCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.A340T	DO42969	UCEC	ICGC	PTPGTS	DEG_SCF_FBW7_1	0.1111
p.D325G	SIDM01090	Colorectal Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.2778
p.D325G	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	0.2778
p.D325G	RKO	large_intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.2778
p.P341Q	SIDM00411	Pancreatic Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.P341Q	ACH-000332	Pancreatic Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.P341Q	YAPC	pancreas	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.P329L	ACH-001566	Skin Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	0.7582
p.P334Q	YAPC	pancreas	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.7222
p.D318G	RKO	large_intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.0833
p.D331G	RKO	large_intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.7198
p.D330G	RKO	large_intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.7198
p.D335G	RKO	large_intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.25
p.D329Y	NCI-H2009	lung	COSMIC	PTPGTS	DEG_SCF_FBW7_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_SCF_FBW7_1	102:107	PTPGTS	FBXW7	0.9977	More...
Q04726	Transducin-like enhancer protein 3	DEG_SCF_FBW7_1	327:332	PTPGTS	FBXW7	0.9977	More...
Q9P202	Whirlin	DEG_SCF_FBW7_1	635:640	PTPGTS	FBXW7	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons