DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PTPGTS
Uniprot ID:
Q9P202
Source protein:
Whirlin
Source gene:
WHRN
Class:
DEG_SCF_FBW7_1
Location:
635:640
E3 ligase:
FBXW7
DEGRON score:
0.9542
ASA_SCORE:
74.5167
COIL:
0.9097
CONS_SCORE:
0.3028
DSS_SCORE:
0.7427
HELIX:
0.0207
FCONS_SCORE:
0.9064
RIG_SCORE:
0.5568
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R627C
SIDM00820
Kidney Carcinoma
GDSC
PTPGTS
DEG_SCF_FBW7_1
0.1111
p.R627C
RCC-ER
kidney
COSMIC
PTPGTS
DEG_SCF_FBW7_1
0.1111
Drug responses associated with WHRN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPGTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15014
Zinc finger protein 609
DEG_SCF_FBW7_1
102:107
PTPGTS
FBXW7
0.9977
More...
Q04726
Transducin-like enhancer protein 3
DEG_SCF_FBW7_1
327:332
PTPGTS
FBXW7
0.9977
More...
Q9P202
Whirlin
DEG_SCF_FBW7_1
635:640
PTPGTS
FBXW7
0.9542
More...