DegronMD - Q04726(TLE3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D282H	TCGA-46-6025	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1111
p.D282H	DO26644	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1111
p.E255D	TCGA-6A-AB49	LUSC	TCGA	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.2778
p.E255D	DO52020	LUSC	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.2778
p.A283V	TCGA-AA-3984	COAD	TCGA	VASSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1389
p.A283V	DO9002	COAD	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1389
p.R261Q	TCGA-AZ-6601	COAD	TCGA	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6218
p.R261Q	DO8119	COAD	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6218
p.R261Q	DO233205	GACA	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6218
p.S289T	TCGA-B0-5703	KIRC	TCGA	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.75
p.S339L	TCGA-B7-5816	STAD	TCGA	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1389
p.S339L	TCGA-B7-5816	STAD	TCGA	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.S339L	TCGA-FI-A2D0	UCEC	TCGA	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1389
p.S339L	TCGA-FI-A2D0	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.S339L	DO38599	STAD	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1389
p.S339L	DO38599	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.S339L	DO43891	UCEC	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1389
p.S339L	DO43891	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.P341R	TCGA-C8-A134	BRCA	TCGA	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.P341R	TCGA-C8-A134	BRCA	TCGA	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1111
p.P341R	DO1316	BRCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.P341R	DO1316	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1111
p.P269S	TCGA-EE-A29X	SKCM	TCGA	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1667
p.P269S	DO222510	MELA	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1667
p.P269S	DO37595	SKCM	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1667
p.H266R	TCGA-MX-A5UJ	STAD	TCGA	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.25
p.H266R	DO48547	STAD	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.25
p.R290C	DO229389	BTCA	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.8301
p.R290C	DO43106	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.8301
p.A320T	DO9788	COAD	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1389
p.A320T	DO9788	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.0833
p.A320T	DO41331	UCEC	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1389
p.A320T	DO41331	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.0833
p.H266N	DO228925	LICA	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.25
p.A300S	DO228941	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation substituting flanking lysine	0.2778
p.A300S	DO229242	THCA	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation substituting flanking lysine	0.2778
p.L337I	DO228948	LICA	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1944
p.L337I	DO228948	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.H266Q	DO228948	LICA	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.25
p.P327T	DO228971	LICA	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7031
p.T333K	DO229022	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.8417
p.T333K	DO229008	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.8417
p.A326V	DO220854	MELA	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.3056
p.A326V	DO220854	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.25
p.P341T	DO27899	ORCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.P341T	DO27899	ORCA	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1111
p.S299P	DO229275	THCA	ICGC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.6389
p.K253T	DO223286	UCEC	ICGC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation blocking phosphorylation signal	0.6667
p.A340T	DO42969	UCEC	ICGC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.1111
p.A340T	DO42969	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1389
p.D325G	SIDM01090	Colorectal Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2778
p.D325G	SIDM01090	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.D325G	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2778
p.D325G	ACH-000943	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.D325G	RKO	large intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.2778
p.D325G	RKO	large intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.P341Q	SIDM00411	Pancreatic Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.P341Q	SIDM00411	Pancreatic Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1111
p.P341Q	ACH-000332	Pancreatic Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.P341Q	ACH-000332	Pancreatic Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1111
p.P341Q	YAPC	pancreas	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.P341Q	YAPC	pancreas	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1111
p.A258T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6028
p.A258T	SIDM00217	Colorectal Carcinoma	GDSC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6028
p.A258T	ACH-000999	Colon/Colorectal Cancer	CCLE	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6028
p.A258T	ACH-001738	Leukemia	CCLE	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6028
p.A258T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6028
p.A258T	SNU-1040	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.6028
p.S299F	SIDM01064	Hodgkin's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.6389
p.S299F	ACH-000267	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.6389
p.S299F	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.6389
p.P329L	ACH-001566	Skin Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7582
p.P329L	ACH-001566	Skin Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7582
p.A263T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.7139
p.A263T	SNU-1040	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation altering degron motif	0.7139
p.P334Q	YAPC	pancreas	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation blocking phosphorylation signal	0.7222
p.P334Q	YAPC	pancreas	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation blocking phosphorylation signal	0.75
p.A290S	SK-N-FI	autonomic ganglia	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7588
p.S304F	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0556
p.D318G	RKO	large intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.0833
p.S292F	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.9093
p.A264T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.3056
p.A264T	SNU-1040	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.3056
p.P285Q	YAPC	pancreas	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.6389
p.A268T	SNU-1040	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1944
p.A268T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1944
p.D331G	RKO	large intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7198
p.D331G	RKO	large intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7198
p.Y248C	LS-180	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.0833
p.D330G	RKO	large intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7198
p.D330G	RKO	large intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7198
p.I294L	MFE-296	endometrium	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7174
p.A251T	SNU-1040	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1667
p.A251T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1667
p.G295S	CHP-134	autonomic ganglia	COSMIC	VASSS	DEG_SPOP_SBC_1	290:294	Mutation blocking phosphorylation signal	0.75
p.D335G	RKO	large intestine	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation rewiring degron network	0.25
p.D335G	RKO	large intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.I343L	MFE-296	endometrium	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation substituting flanking lysine	0.1667
p.D329Y	NCI-H2009	lung	COSMIC	PTPGTS	DEG_SCF_FBW7_1	327:332	Mutation altering degron motif	0.7325
p.D329Y	NCI-H2009	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7325
p.D269G	RKO	large intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	257:263	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLE3

UniProt ID: Q04726

Entrez ID: 7090

Protein name: Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TLE3 in