DegronMD

Uniprot ID: Q04726

Source protein: Transducin-like enhancer protein 3

Source gene: TLE3

Class: DEG_SCF_FBW7_1

Location: 257:263

E3 ligase: FBXW7

DEGRON score: 0.9579

ASA_SCORE: 77.9

COIL: 0.9447

CONS_SCORE: 0.4242

DSS_SCORE: 0.755

HELIX: 0.0191

FCONS_SCORE: 0.951

RIG_SCORE: 0.6035

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E255D	TCGA-6A-AB49	LUSC	TCGA	PATPRVS	DEG_SCF_FBW7_1	0.2778
p.E255D	DO52020	LUSC	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.2778
p.R261Q	TCGA-AZ-6601	COAD	TCGA	PATPRVS	DEG_SCF_FBW7_1	0.6218
p.R261Q	DO8119	COAD	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.6218
p.R261Q	DO233205	GACA	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.6218
p.P269S	TCGA-EE-A29X	SKCM	TCGA	PATPRVS	DEG_SCF_FBW7_1	0.1667
p.P269S	DO222510	MELA	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.1667
p.P269S	DO37595	SKCM	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.1667
p.H266R	TCGA-MX-A5UJ	STAD	TCGA	PATPRVS	DEG_SCF_FBW7_1	0.25
p.H266R	DO48547	STAD	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.25
p.H266N	DO228925	LICA	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.25
p.H266Q	DO228948	LICA	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.25
p.K253T	DO223286	UCEC	ICGC	PATPRVS	DEG_SCF_FBW7_1	0.6667
p.A258T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PATPRVS	DEG_SCF_FBW7_1	0.6028
p.A258T	SIDM00217	Colorectal Carcinoma	GDSC	PATPRVS	DEG_SCF_FBW7_1	0.6028
p.A258T	ACH-000999	Colon/Colorectal Cancer	CCLE	PATPRVS	DEG_SCF_FBW7_1	0.6028
p.A258T	ACH-001738	Leukemia	CCLE	PATPRVS	DEG_SCF_FBW7_1	0.6028
p.A258T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.6028
p.A258T	SNU-1040	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.6028
p.A263T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.7139
p.A263T	SNU-1040	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.7139
p.A264T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.3056
p.A264T	SNU-1040	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.3056
p.A268T	SNU-1040	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.1944
p.A268T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.1944
p.Y248C	LS-180	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.0833
p.A251T	SNU-1040	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.1667
p.A251T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.1667
p.D269G	RKO	large_intestine	COSMIC	PATPRVS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATPRVS

Degron related mutations and impact score

Drug responses associated with TLE3 mutations

All proteins holding degron of PATPRVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04726	Transducin-like enhancer protein 3	DEG_SCF_FBW7_1	257:263	PATPRVS	FBXW7	0.9579	More...