DegronMD - Q9Y6C2(EMILIN1)

FUNCTION: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

GO - Biological processes (BP): aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell act... View more >>

GO - Molecular function (MF): extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]

GO - Cellular component (CC): collagen-containing extracellular matrix [GO:0062023]; collagen trimer [GO:0005581]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DRERLRAME	DEG_APCC_DBOX_1	APC,CDC20,FZR1	EMILIN-1	319:327	More..
PASST	DEG_SPOP_SBC_1	SPOP	EMILIN-1	139:143	More..
PPGY	ITCH	ITCH,NEDD4	EMILIN-1	397:400	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R322W	TCGA-EY-A2OM	UCEC	TCGA	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.7523
p.R322W	DO43025	UCEC	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.7523
p.P398A	ACH-001289	Rhabdoid	CCLE	PPGY	ITCH	397:400	Mutation altering degron motif	0.7503
p.G399A	DO229191	THCA	ICGC	PPGY	ITCH	397:400	Mutation altering degron motif	0.6429
p.R322Q	DO227802	COCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.6218
p.R322Q	DO233210	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.6218
p.R322Q	DO229229	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.6218
p.E321K	DO232224	PBCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.591
p.A140V	TCGA-AX-A2HD	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.5825
p.A140V	DO42608	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.5825
p.K328M	DO229264	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.3056
p.L147M	TCGA-FS-A1Z4	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.L147M	DO37462	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.A331V	DO229229	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.2222
p.P135A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.P135A	SIDM00166	Other Solid Cancers	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.P135A	SIDM01447	Glioblastoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.A134T	DO229389	BTCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.Q149R	DO229010	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.Q149R	DO229013	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667

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No resistance data available for this Degron.

Kaplan plot for EMILIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EMILIN1

UniProt ID: Q9Y6C2

Entrez ID: 11117

Protein name: EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for EMILIN1 in