DegronMD - Q9Y6C2(EMILIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A140V	TCGA-AX-A2HD	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.5825
p.A140V	DO42608	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.5825
p.R152C	TCGA-CN-6024	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R152C	DO15326	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R322W	TCGA-EY-A2OM	UCEC	TCGA	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.7523
p.R322W	DO43025	UCEC	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.7523
p.L147M	TCGA-FS-A1Z4	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.L147M	DO37462	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.A134T	DO229389	BTCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.R322Q	DO227802	COCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.6218
p.R322Q	DO233210	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.6218
p.R322Q	DO229229	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.6218
p.Q149R	DO229010	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.Q149R	DO229013	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.Q149R	DO229016	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.Q149R	DO229003	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.Q149R	DO229005	COCA	ICGC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R336Q	DO233087	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.0833
p.R313H	DO233679	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.1667
p.R313H	DO229015	LICA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.1667
p.R313H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.1667
p.G311C	DO229015	LICA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.1111
p.E321K	DO232224	PBCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation altering degron motif	0.591
p.G399A	DO229191	THCA	ICGC	PPGY	ITCH	397:400	Mutation altering degron motif	0.6429
p.K328M	DO229264	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.3056
p.A331V	DO229229	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	319:327	Mutation rewiring degron network	0.2222
p.P135A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.P135A	SIDM00166	Other Solid Cancers	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.P135A	SIDM01447	Glioblastoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.R149Q	SIDM01265	Plasma Cell Myeloma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00967	Ovarian Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00454	Rhabdomyosarcoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00210	Ovarian Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00879	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00844	Burkitt's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00863	Burkitt's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00720	Mesothelioma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00628	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM00641	Burkitt's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R149Q	SIDM01664	Prostate Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R406H	ACH-000657	Ovarian Cancer	CCLE	PPGY	ITCH	397:400	Mutation rewiring degron network	0.1667
p.P398A	ACH-001289	Rhabdoid	CCLE	PPGY	ITCH	397:400	Mutation altering degron motif	0.7503
p.E131D	ACH-001409	Bladder Cancer	CCLE	PASST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111

Kaplan plot for EMILIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EMILIN1

UniProt ID: Q9Y6C2

Entrez ID: 11117

Protein name: EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EMILIN1 in