DegronMD

Uniprot ID: Q9Y6C2

Source protein: EMILIN-1

Source gene: EMILIN1

Class: DEG_APCC_DBOX_1

Location: 319:327

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5565

ASA_SCORE: 109.1444

COIL: 0.024

CONS_SCORE: 0.6003

DSS_SCORE: 0.3978

HELIX: 0.9774

FCONS_SCORE: 1.0803

RIG_SCORE: 0.7982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R322W	TCGA-EY-A2OM	UCEC	TCGA	DRERLRAME	DEG_APCC_DBOX_1	0.7523
p.R322W	DO43025	UCEC	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.7523
p.R322Q	DO227802	COCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.6218
p.R322Q	DO233210	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.6218
p.R322Q	DO229229	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.6218
p.R336Q	DO233087	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.0833
p.R313H	DO233679	GACA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.1667
p.R313H	DO229015	LICA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.1667
p.R313H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRERLRAME	DEG_APCC_DBOX_1	0.1667
p.G311C	DO229015	LICA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.1111
p.E321K	DO232224	PBCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.591
p.K328M	DO229264	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.3056
p.A331V	DO229229	THCA	ICGC	DRERLRAME	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6C2	EMILIN-1	DEG_APCC_DBOX_1	319:327	DRERLRAME	APC,CDC20,FZR1	0.5565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons