DegronMD - Q9C0I3(CCSER1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R489G	TCGA-2H-A9GR	ESCA	TCGA	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.2222
p.R64H	TCGA-2W-A8YY	CESC	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.R64H	TCGA-D1-A167	UCEC	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.R64H	TCGA-DU-A76L	LGG	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.R64H	DO223732	CESC	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.R64H	DO50151	LGG	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.R64H	DO40978	UCEC	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.S45F	TCGA-55-6972	LUAD	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7982
p.S45F	DO25010	LUAD	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7982
p.R640I	TCGA-55-8089	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.R640I	DO23690	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.S36C	TCGA-77-8140	LUSC	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.S36C	DO26834	LUSC	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.P46S	TCGA-86-6851	LUAD	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.P46S	TCGA-DA-A1I1	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.P46S	DO23798	LUAD	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.P46S	DO37966	SKCM	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.R59Q	TCGA-A6-3808	COAD	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.R59Q	TCGA-EE-A20C	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.R59Q	DO8408	COAD	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.R59Q	DO47665	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.S45C	TCGA-AJ-A3QS	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7541
p.S45C	DO41349	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7541
p.R492I	TCGA-AP-A1E0	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.3056
p.R492I	DO43154	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.3056
p.R451H	TCGA-B5-A11E	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation altering degron motif	0.7133
p.R451H	DO41644	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation altering degron motif	0.7133
p.G57C	TCGA-BF-A1Q0	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1944
p.G57C	DO47374	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1944
p.H72Q	TCGA-CV-A45Z	HNSC	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.H72Q	DO52064	HNSC	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.D647V	TCGA-D1-A1NY	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.25
p.D647V	DO42512	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.25
p.G40C	TCGA-D3-A1Q3	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.G40C	DO47509	SKCM	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.L642F	TCGA-D3-A8GL	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1111
p.L642F	DO50287	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1111
p.S32L	TCGA-D6-6517	HNSC	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.S32L	DO15302	HNSC	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0833
p.R461Q	TCGA-E6-A1LX	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.0833
p.R461Q	TCGA-EO-A3B0	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.0833
p.R461Q	DO219773	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.0833
p.R461Q	DO41020	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.0833
p.R451C	TCGA-EO-A22U	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation altering degron motif	0.719
p.R451C	DO43755	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation altering degron motif	0.719
p.S69T	TCGA-ER-A2NC	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6005
p.S69T	DO47318	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6005
p.S47F	TCGA-KO-8404	KICH	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.S47F	DO220545	KICH	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.V39F	TCGA-LA-A7SW	LUSC	TCGA	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.V39F	DO52024	LUSC	ICGC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.E664V	TCGA-MI-A75I	LIHC	TCGA	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.E664V	DO49712	LIHC	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.R640G	TCGA-UB-A7MB	LIHC	TCGA	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.R640G	DO52318	LIHC	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.R64C	TCGA-YG-AA3N	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.719
p.R64C	DO220899	MELA	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.719
p.R64C	DO51298	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.719
p.E664Q	DO6561	CLLE	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.K79Q	DO234210	ESAD	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation substituting flanking lysine	0.1667
p.L503F	DO228976	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1667
p.A440S	DO228985	LICA	ICGC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.1389
p.K490N	DO229019	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation substituting flanking lysine	0.3611
p.M500I	DO229034	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.25
p.L506F	DO229035	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.0833
p.H71N	DO50851	LIRI	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.2778
p.R59H	DO222775	MELA	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.25
p.P650L	DO222775	MELA	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.7582
p.A437T	DO232761	PBCA	ICGC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.0556
p.S645R	DO37627	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1944
p.I456V	SIDM00425	Ovarian Carcinoma	GDSC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.2222
p.I456V	ACH-000663	Ovarian Cancer	CCLE	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.2222
p.I456V	OVTOKO	ovary	COSMIC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.2222
p.E457D	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.1944
p.E457D	ACH-000953	Leukemia	CCLE	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.1944
p.E457D	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LSPFRE	LIG_APCC_ABBA_1	447:452	Mutation rewiring degron network	0.1944
p.S61T	SIDM00876	Non-Cancerous	GDSC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.S61T	SIDM00877	Breast Carcinoma	GDSC	IFRTPSIS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.G40R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.G40R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCSER1

UniProt ID: Q9C0I3

Entrez ID: 401145

Protein name: Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCSER1 in