DegronMD

Uniprot ID: Q9C0I3

Source protein: Serine-rich coiled-coil domain-containing protein 1

Source gene: CCSER1

Class: DEG_SPOP_SBC_1

Location: 41:45

E3 ligase: SPOP

DEGRON score: 0.9419

ASA_SCORE: 86.52

COIL: 0.8558

CONS_SCORE: 0.6782

DSS_SCORE: 0.6391

HELIX: 0.012

FCONS_SCORE: 0.8885

RIG_SCORE: 0.5342

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S45F	TCGA-55-6972	LUAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S45F	DO25010	LUAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S36C	TCGA-77-8140	LUSC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1944
p.S36C	DO26834	LUSC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.P46S	TCGA-86-6851	LUAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.3056
p.P46S	TCGA-DA-A1I1	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.3056
p.P46S	DO23798	LUAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.P46S	DO37966	SKCM	ICGC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.S45C	TCGA-AJ-A3QS	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7541
p.S45C	DO41349	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7541
p.G40C	TCGA-D3-A1Q3	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.3056
p.G40C	DO47509	SKCM	ICGC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.S32L	TCGA-D6-6517	HNSC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.0833
p.S32L	DO15302	HNSC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.0833
p.S47F	TCGA-KO-8404	KICH	TCGA	VHSSS	DEG_SPOP_SBC_1	0.2778
p.S47F	DO220545	KICH	ICGC	VHSSS	DEG_SPOP_SBC_1	0.2778
p.V39F	TCGA-LA-A7SW	LUSC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.2778
p.V39F	DO52024	LUSC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.2778
p.G40R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.G40R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons