SOCS6
UniProt ID: O14544
Entrez ID: 9306
Protein name: Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subs...
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.
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GO - Biological processes (BP):
defense response [GO:0006952]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; proteasomal protein catabolic process [GO:0...
defense response [GO:0006952]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of growth [GO:0040008]
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GO - Molecular function (MF):
1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]...
1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; phosphatidylinositol 3-kinase complex [GO:0005942]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; phosphatidylinositol 3-kinase complex [GO:0005942]
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SOCS6
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Kaplan plot for SOCS6 in
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*NOTE: the Kaplan plots were collected from OncoLnc