DegronMD

Uniprot ID: O14544

Source protein: Suppressor of cytokine signaling 6

Source gene: SOCS6

Class: DEG_SPOP_SBC_1

Location: 159:163

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 73.82

COIL: 0.8642

CONS_SCORE: 0.5222

DSS_SCORE: 0.4644

HELIX: 0.0252

FCONS_SCORE: 0.9854

RIG_SCORE: 0.6688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K173T	TCGA-BS-A0UJ	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.5
p.K173T	DO42745	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.5
p.V171I	TCGA-IG-A8O2	ESCA	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1111
p.V171I	DO8858	COAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1111
p.N169D	TCGA-VQ-A924	STAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1667
p.N169D	DO51795	STAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.M151I	DO229032	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1111
p.P164R	SIDM00190	Melanoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.P164R	SIDM01715	Non-Cancerous	GDSC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.P164R	ACH-002097	Skin Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.3056
p.P164R	ACH-002347	Non-Cancerous	CCLE	VHSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons