DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: DEG_SPOP_SBC_1

Location: 231:235

E3 ligase: SPOP

DEGRON score: 0.7399

ASA_SCORE: 81.2

COIL: 0.7556

CONS_SCORE: 0.738

DSS_SCORE: 0.7006

HELIX: 0.2072

FCONS_SCORE: 1.0208

RIG_SCORE: 0.6251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D244Y	TCGA-VQ-A8P2	STAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.0833
p.D244Y	DO51761	STAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.0833
p.S226R	DO222762	COCA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.H232R	DO48225	ESCA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7133
p.H232R	SIDM01090	Colorectal Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.7133
p.H232R	ACH-000943	Colon/Colorectal Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.7133
p.H232R	RKO	large_intestine	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.7133
p.H232Q	SIDM00789	Colorectal Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.647
p.H232Q	ACH-000997	Colon/Colorectal Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.647
p.H232Q	HCT-15	large_intestine	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.647
p.Q229R	SIDM01146	Gastric Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.2778
p.Q229R	NCI-SNU-1	stomach	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.2778
p.I245M	SIDM00273	Glioblastoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.0556
p.I245M	ACH-000756	Brain Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.0556
p.I245M	GI-1	central_nervous_system	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons