DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: DEG_SPOP_SBC_1

Location: 1375:1379

E3 ligase: SPOP

DEGRON score: 0.7433

ASA_SCORE: 79.16

COIL: 0.8352

CONS_SCORE: 0.3832

DSS_SCORE: 0.5275

HELIX: 0.0844

FCONS_SCORE: 0.9495

RIG_SCORE: 0.6783

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1379F	TCGA-AJ-A3EL	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S1379F	TCGA-AN-A046	BRCA	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S1379F	DO1285	BRCA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S1379F	DO41542	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7982
p.V1375D	TCGA-EO-A22R	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7785
p.V1375D	DO42713	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7785
p.A1383D	TCGA-G4-6586	COAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.2222
p.A1383D	DO9698	COAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.2222
p.P1370S	TCGA-W3-A824	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1944
p.P1370S	DO51271	SKCM	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.N1381D	DO218796	BRCA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.2778
p.P1370H	SIDM00654	Small Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.P1370H	ACH-000866	Lung Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.1944
p.P1370H	NCI-H1048	lung	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.S1368R	SIDM00654	Small Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.1389
p.S1368R	ACH-000866	Lung Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.1389
p.S1368R	NCI-H1048	lung	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.1389
p.R1386P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.1389
p.R1386P	ACH-000797	Non-Cancerous	CCLE	VHSSS	DEG_SPOP_SBC_1	0.1389
p.S1379Y	SIDM01588	Endometrial Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.712
p.S1379Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons