DegronMD - Q8N5C8(TAB3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q246H	TCGA-06-1084	GBM	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.647
p.Q246H	DO11106	GBM	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.647
p.P329T	TCGA-22-4613	LUSC	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.P329T	DO26468	LUSC	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.A349V	TCGA-33-AASD	LUSC	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0833
p.A349V	DO219127	LUSC	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0833
p.G413W	TCGA-33-AASL	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.G413W	DO219133	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.N75K	TCGA-42-2591	OV	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.5806
p.N75K	DO31654	OV	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.5806
p.P410L	TCGA-43-A475	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.P410L	DO45431	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.P410L	DO229491	SKCA	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.P249L	TCGA-49-AAR9	LUAD	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7582
p.P249L	DO218921	LUAD	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7582
p.P249L	DO229465	SKCA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7582
p.G413V	TCGA-60-2714	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.G413V	DO26530	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.P178Q	TCGA-66-2734	LUSC	TCGA	PPSY	ITCH	181:184	Mutation rewiring degron network	0.25
p.P178Q	DO26430	LUSC	ICGC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.25
p.Q110R	TCGA-A5-A1OF	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.Q110R	DO42568	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.Q343H	TCGA-AP-A051	UCEC	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.25
p.Q343H	TCGA-ER-A1A1	SKCM	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.25
p.Q343H	DO37413	SKCM	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.25
p.Q343H	DO42673	UCEC	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.25
p.H186R	TCGA-AP-A059	UCEC	TCGA	PPSY	ITCH	181:184	Mutation rewiring degron network	0.2778
p.H186R	DO41361	UCEC	ICGC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.2778
p.R242I	TCGA-AP-A0LM	UCEC	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.25
p.R242I	DO43306	UCEC	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.25
p.R68I	TCGA-AP-A1E0	UCEC	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8102
p.R68I	TCGA-AX-A2HC	UCEC	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8102
p.R68I	DO43154	UCEC	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8102
p.R68I	DO41572	UCEC	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8102
p.L399M	TCGA-AX-A1CE	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1667
p.L399M	DO42280	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1667
p.T248M	TCGA-AX-A2HC	UCEC	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7423
p.T248M	TCGA-F4-6807	COAD	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7423
p.T248M	DO9716	COAD	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7423
p.T248M	DO41572	UCEC	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7423
p.S415C	TCGA-BR-8361	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1667
p.S415C	DO48032	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1667
p.S409F	TCGA-BS-A0UV	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.9093
p.S409F	DO42793	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.9093
p.Y190F	TCGA-BS-A0WQ	UCEC	TCGA	PPSY	ITCH	181:184	Mutation rewiring degron network	0.1667
p.Y190F	DO42705	UCEC	ICGC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.1667
p.G344E	TCGA-CA-6718	COAD	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.2222
p.G344E	DO7801	COAD	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.2222
p.Y184C	TCGA-DF-A2KU	UCEC	TCGA	PPSY	ITCH	181:184	Mutation altering degron motif	0.7087
p.Y184C	DO223286	UCEC	ICGC	PPSY	ITCH	181:184	Mutation altering degron motif	0.7087
p.T244I	TCGA-EL-A3GW	THCA	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.3056
p.T244I	DO38930	THCA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.3056
p.P330R	TCGA-FD-A3B8	BLCA	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1389
p.P330R	DO607	BLCA	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1389
p.P109S	TCGA-GC-A3RC	BLCA	TCGA	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.P109S	DO816	BLCA	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.P109S	DO50374	ESAD	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.S411L	TCGA-IR-A3LH	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.S411L	DO44381	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.H331Y	TCGA-KU-A66S	HNSC	TCGA	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1667
p.H331Y	DO44456	HNSC	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1667
p.T404M	TCGA-NH-A5IV	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation blocking phosphorylation signal	0.75
p.T404M	DO49095	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation blocking phosphorylation signal	0.75
p.A171V	TCGA-O2-A52V	LUSC	TCGA	PPSY	ITCH	181:184	Mutation rewiring degron network	0.0556
p.A171V	DO219223	LUSC	ICGC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.0556
p.M66L	TCGA-ZP-A9D0	LIHC	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.M66L	DO52331	LIHC	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.P437T	DO225192	BRCA	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation altering degron motif	0.7031
p.H260Y	DO225148	BRCA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1111
p.F75L	DO227935	BRCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6981
p.S82T	DO222682	BTCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation blocking phosphorylation signal	0.5833
p.T82I	DO222973	BTCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation blocking phosphorylation signal	0.5833
p.K62N	DO7801	COAD	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.P61T	DO222762	COCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1667
p.Q433L	DO223019	ESCA	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation rewiring degron network	0.2222
p.N93D	DO228507	GACA	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.S103G	DO233934	GACA	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.8104
p.R70I	DO22237	LGG	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6991
p.Q110K	DO228976	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.T235K	DO228986	LICA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.0556
p.T248K	DO229029	LICA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7306
p.P449T	DO229022	LICA	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation rewiring degron network	0.1944
p.L71I	DO229027	LICA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.7174
p.P418T	DO229034	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0833
p.H73N	DO229037	LICA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6312
p.L98M	DO229008	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.3056
p.V427M	DO52666	MALY	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation rewiring degron network	0.0556
p.P245S	DO222837	MELA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.6752
p.P329Q	DO232056	ORCA	ICGC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.S83T	DO232016	ORCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation blocking phosphorylation signal	0.5556
p.M185I	DO28521	OV	ICGC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.3056
p.R65M	DO229211	THCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2778
p.M185V	DO234133	THCA	ICGC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.3056
p.R189Q	SIDM01943	Colorectal Carcinoma	GDSC	PPSY	ITCH	181:184	Mutation rewiring degron network	0.1944
p.V348L	SIDM00545	Melanoma	GDSC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.S408N	SIDM00253	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.818
p.S408N	ACH-002284	Neuroblastoma	CCLE	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.818
p.S408N	NB6	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.818
p.T327I	SIDM00684	Glioblastoma	GDSC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0556
p.T327I	ACH-000595	Brain Cancer	CCLE	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0556
p.T327I	LN-229	central nervous system	COSMIC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.0556
p.T440A	SIDM00845	Burkitt's Lymphoma	GDSC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation altering degron motif	0.825
p.T440A	SIDM01519	Head and Neck Carcinoma	GDSC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation altering degron motif	0.825
p.T440A	ACH-000786	Lymphoma	CCLE	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation altering degron motif	0.825
p.T440A	ACH-000992	Head and Neck Cancer	CCLE	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation altering degron motif	0.825
p.T440A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSCTPSPS	DEG_SCF_FBW7_1	437:444	Mutation altering degron motif	0.825
p.A112T	SIDM00845	Burkitt's Lymphoma	GDSC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.A112T	ACH-000786	Lymphoma	CCLE	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.A112T	ACH-000992	Head and Neck Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.Q91H	SIDM00845	Burkitt's Lymphoma	GDSC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1111
p.H100Q	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.647
p.H100Q	ACH-000583	Lymphoma	CCLE	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.647
p.H100Q	MC116	haematopoietic and lymphoid tissue	COSMIC	VHSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.647
p.P329L	SIDM00254	Neuroblastoma	GDSC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.P329L	ACH-002283	Neuroblastoma	CCLE	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.P329L	NB5	autonomic ganglia	COSMIC	PPSY	ITCH	337:340	Mutation rewiring degron network	0.1111
p.S239L	SIDM00224	Mesothelioma	GDSC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1667
p.R242K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.25
p.R242K	ACH-000912	Lung Cancer	CCLE	PQSTPWQS	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.25
p.S82R	ACH-001354	Neuroblastoma	CCLE	NRNRLLHIN	DEG_APCC_DBOX_1	67:75	Mutation blocking phosphorylation signal	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAB3

UniProt ID: Q8N5C8

Entrez ID: 257397

Protein name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAB3 in