DegronMD

Uniprot ID: Q8N5C8

Source protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Source gene: TAB3

Class: DEG_SCF_FBW7_1

Location: 245:252

E3 ligase: FBXW7

DEGRON score: 0.9757

ASA_SCORE: 95.4125

COIL: 0.9466

CONS_SCORE: 0.4619

DSS_SCORE: 0.7947

HELIX: 0.0223

FCONS_SCORE: 1.1556

RIG_SCORE: 0.5711

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P249L	TCGA-49-AAR9	LUAD	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	0.7582
p.P249L	DO218921	LUAD	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.7582
p.P249L	DO229465	SKCA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.7582
p.T248M	TCGA-AX-A2HC	UCEC	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	0.7423
p.T248M	TCGA-F4-6807	COAD	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	0.7423
p.T248M	DO9716	COAD	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.7423
p.T248M	DO41572	UCEC	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.7423
p.T248K	DO229029	LICA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.7306
p.P245S	DO222837	MELA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.6752
p.Q246H	TCGA-06-1084	GBM	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	0.647
p.Q246H	DO11106	GBM	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.647
p.T244I	TCGA-EL-A3GW	THCA	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	0.3056
p.T244I	DO38930	THCA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.3056
p.R242I	TCGA-AP-A0LM	UCEC	TCGA	PQSTPWQS	DEG_SCF_FBW7_1	0.25
p.R242I	DO43306	UCEC	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.25
p.R242K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PQSTPWQS	DEG_SCF_FBW7_1	0.25
p.R242K	ACH-000912	Lung Cancer	CCLE	PQSTPWQS	DEG_SCF_FBW7_1	0.25
p.S239L	SIDM00224	Mesothelioma	GDSC	PQSTPWQS	DEG_SCF_FBW7_1	0.1667
p.H260Y	DO225148	BRCA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.1111
p.T235K	DO228986	LICA	ICGC	PQSTPWQS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SCF_FBW7_1	245:252	PQSTPWQS	FBXW7	0.9757	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons