DegronMD

Uniprot ID: Q8N5C8

Source protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Source gene: TAB3

Class: DEG_APCC_DBOX_1

Location: 67:75

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9525

ASA_SCORE: 75.3778

COIL: 0.472

CONS_SCORE: 0.5107

DSS_SCORE: 0.4121

HELIX: 0.1207

FCONS_SCORE: 1.1838

RIG_SCORE: 0.7602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N75K	TCGA-42-2591	OV	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	0.5806
p.N75K	DO31654	OV	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.5806
p.R68I	TCGA-AP-A1E0	UCEC	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	0.8102
p.R68I	TCGA-AX-A2HC	UCEC	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	0.8102
p.R68I	DO43154	UCEC	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.8102
p.R68I	DO41572	UCEC	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.8102
p.M66L	TCGA-ZP-A9D0	LIHC	TCGA	NRNRLLHIN	DEG_APCC_DBOX_1	0.3056
p.M66L	DO52331	LIHC	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.3056
p.F75L	DO227935	BRCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.6981
p.S82T	DO222682	BTCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.5833
p.T82I	DO222973	BTCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.5833
p.K62N	DO7801	COAD	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.1944
p.P61T	DO222762	COCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.1667
p.R70I	DO22237	LGG	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.6991
p.L71I	DO229027	LICA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.7174
p.H73N	DO229037	LICA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.6312
p.S83T	DO232016	ORCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.5556
p.R65M	DO229211	THCA	ICGC	NRNRLLHIN	DEG_APCC_DBOX_1	0.2778
p.S82R	ACH-001354	Neuroblastoma	CCLE	NRNRLLHIN	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_APCC_DBOX_1	67:75	NRNRLLHIN	APC,CDC20,FZR1	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons