DegronMD

Uniprot ID: Q8N5C8

Source protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Source gene: TAB3

Class: DEG_SPOP_SBC_1

Location: 99:103

E3 ligase: SPOP

DEGRON score: 0.9941

ASA_SCORE: 68.08

COIL: 0.7478

CONS_SCORE: 0.5205

DSS_SCORE: 0.5966

HELIX: 0.03

FCONS_SCORE: 1.1564

RIG_SCORE: 0.6372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q110R	TCGA-A5-A1OF	UCEC	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1389
p.Q110R	DO42568	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1389
p.P109S	TCGA-GC-A3RC	BLCA	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1667
p.P109S	DO816	BLCA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.P109S	DO50374	ESAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.N93D	DO228507	GACA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.S103G	DO233934	GACA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.8104
p.Q110K	DO228976	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1389
p.L98M	DO229008	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.A112T	SIDM00845	Burkitt's Lymphoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.0833
p.A112T	ACH-000786	Lymphoma	CCLE	VHSSS	DEG_SPOP_SBC_1	0.0833
p.A112T	ACH-000992	Head and Neck Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.0833
p.Q91H	SIDM00845	Burkitt's Lymphoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.1111
p.H100Q	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.647
p.H100Q	ACH-000583	Lymphoma	CCLE	VHSSS	DEG_SPOP_SBC_1	0.647
p.H100Q	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons