DegronMD - Q7Z4V0(ZNF438)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q231K	TCGA-05-4390	LUAD	TCGA	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1111
p.Q231K	TCGA-05-4390	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1389
p.E706Q	TCGA-AO-A03T	BRCA	TCGA	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1389
p.T234I	TCGA-AP-A1DK	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.0556
p.S716F	TCGA-BF-AAP4	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7982
p.S716F	TCGA-EB-A41A	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7982
p.S716F	TCGA-W3-A825	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7982
p.H714R	TCGA-BR-4361	STAD	TCGA	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7133
p.E706D	TCGA-D3-A3CE	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1389
p.S213T	TCGA-IG-A3Y9	ESCA	TCGA	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.25
p.S213T	TCGA-IG-A3Y9	ESCA	TCGA	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1389
p.T219P	DO50442	ESAD	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.7031
p.M220T	DO17313	KIRC	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.7423
p.M220T	DO17313	KIRC	ICGC	PASST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7423
p.K209T	DO223943	KIRP	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1389
p.T707N	DO229031	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.A231E	DO229037	LICA	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1111
p.A231E	DO229037	LICA	ICGC	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1389
p.N230S	DO26575	LUSC	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation substituting flanking lysine	0.25
p.N230S	DO26575	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	220:224	Mutation substituting flanking lysine	0.2778
p.S224L	DO219219	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7667
p.L720F	DO220877	MELA	ICGC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.25
p.C708R	DO29930	OV	ICGC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1944
p.P714T	DO38715	STAD	ICGC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7031
p.L223V	DO219773	UCEC	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.6765
p.L223V	DO219773	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6765
p.L223V	DO50075	UCEC	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.6765
p.L223V	DO50075	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6765
p.T718M	DO43306	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.3056
p.A217T	DO42608	UCEC	ICGC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.7139
p.R707K	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.R707K	ACH-000021	Lung Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.R707K	ACH-000033	Lung Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.R707K	NCI-H1693	lung	COSMIC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.P228L	SIDM00761	Small Cell Lung Carcinoma	GDSC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1944
p.P228L	SIDM00761	Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2222
p.P228L	ACH-000752	Lung Cancer	CCLE	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1944
p.P228L	ACH-000752	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2222
p.P228L	NCI-H196	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1944
p.P228L	NCI-H196	lung	COSMIC	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2222
p.E226Q	SIDM00146	Breast Carcinoma	GDSC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.25
p.E226Q	SIDM00146	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.E226Q	ACH-000768	Breast Cancer	CCLE	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.25
p.E226Q	ACH-000768	Breast Cancer	CCLE	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.E226Q	MDA-MB-231	breast	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.25
p.E226Q	MDA-MB-231	breast	COSMIC	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.A218S	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.6477
p.A218S	ACH-000337	Lung Cancer	CCLE	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.6477
p.A218S	NCI-H3122	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.6477
p.A722V	SIDM01394	Kidney Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1944
p.A722V	ACH-000907	Kidney Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1944
p.P710L	ACH-001100		CCLE	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.25
p.L228I	HCC2998	large intestine	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1944
p.L228I	HCC2998	large intestine	COSMIC	PASST	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2222
p.E216Q	MDA-MB-231	breast	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.6744
p.A208S	NCI-H3122	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation rewiring degron network	0.1111
p.V727L	NCI-H460	lung	COSMIC	VHSSS	DEG_SPOP_SBC_1	713:717	Mutation substituting flanking lysine	0.1667
p.P218L	NCI-H196	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.7582
p.Q221R	MFE-319	endometrium	COSMIC	PPATPASS	DEG_SCF_FBW7_1	216:223	Mutation altering degron motif	0.7329
p.Q221R	MFE-319	endometrium	COSMIC	PASST	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF438

UniProt ID: Q7Z4V0

Entrez ID: 220929

Protein name: Zinc finger protein 438

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF438 in