DegronMD

Uniprot ID: Q7Z4V0

Source protein: Zinc finger protein 438

Source gene: ZNF438

Class: DEG_SCF_FBW7_1

Location: 216:223

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 79.45

COIL: 0.9548

CONS_SCORE: 0.4307

DSS_SCORE: 0.7809

HELIX: 0.019

FCONS_SCORE: 1.098

RIG_SCORE: 0.5665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q231K	TCGA-05-4390	LUAD	TCGA	PPATPASS	DEG_SCF_FBW7_1	0.1111
p.S213T	TCGA-IG-A3Y9	ESCA	TCGA	PPATPASS	DEG_SCF_FBW7_1	0.25
p.T219P	DO50442	ESAD	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.7031
p.M220T	DO17313	KIRC	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.7423
p.K209T	DO223943	KIRP	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.1389
p.A231E	DO229037	LICA	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.1111
p.N230S	DO26575	LUSC	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.25
p.L223V	DO219773	UCEC	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.6765
p.L223V	DO50075	UCEC	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.6765
p.A217T	DO42608	UCEC	ICGC	PPATPASS	DEG_SCF_FBW7_1	0.7139
p.P228L	SIDM00761	Small Cell Lung Carcinoma	GDSC	PPATPASS	DEG_SCF_FBW7_1	0.1944
p.P228L	ACH-000752	Lung Cancer	CCLE	PPATPASS	DEG_SCF_FBW7_1	0.1944
p.P228L	NCI-H196	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.1944
p.E226Q	SIDM00146	Breast Carcinoma	GDSC	PPATPASS	DEG_SCF_FBW7_1	0.25
p.E226Q	ACH-000768	Breast Cancer	CCLE	PPATPASS	DEG_SCF_FBW7_1	0.25
p.E226Q	MDA-MB-231	breast	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.25
p.A218S	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	PPATPASS	DEG_SCF_FBW7_1	0.6477
p.A218S	ACH-000337	Lung Cancer	CCLE	PPATPASS	DEG_SCF_FBW7_1	0.6477
p.A218S	NCI-H3122	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.6477
p.L228I	HCC2998	large_intestine	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.1944
p.E216Q	MDA-MB-231	breast	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.6744
p.A208S	NCI-H3122	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.1111
p.P218L	NCI-H196	lung	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.7582
p.Q221R	MFE-319	endometrium	COSMIC	PPATPASS	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4V0	Zinc finger protein 438	DEG_SCF_FBW7_1	216:223	PPATPASS	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons