DegronMD

Uniprot ID: Q7Z4V0

Source protein: Zinc finger protein 438

Source gene: ZNF438

Class: DEG_SPOP_SBC_1

Location: 713:717

E3 ligase: SPOP

DEGRON score: 0.5994

ASA_SCORE: 63.1

COIL: 0.7738

CONS_SCORE: 0.3805

DSS_SCORE: 0.7284

HELIX: 0.1706

FCONS_SCORE: 0.6804

RIG_SCORE: 0.557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E706Q	TCGA-AO-A03T	BRCA	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1389
p.S716F	TCGA-BF-AAP4	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S716F	TCGA-EB-A41A	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7982
p.S716F	TCGA-W3-A825	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7982
p.H714R	TCGA-BR-4361	STAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.7133
p.E706D	TCGA-D3-A3CE	SKCM	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1389
p.T707N	DO229031	LICA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.L720F	DO220877	MELA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.25
p.C708R	DO29930	OV	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.P714T	DO38715	STAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.7031
p.T718M	DO43306	UCEC	ICGC	VHSSS	DEG_SPOP_SBC_1	0.3056
p.R707K	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.R707K	ACH-000021	Lung Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.1667
p.R707K	ACH-000033	Lung Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.1667
p.R707K	NCI-H1693	lung	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.1667
p.A722V	SIDM01394	Kidney Carcinoma	GDSC	VHSSS	DEG_SPOP_SBC_1	0.1944
p.A722V	ACH-000907	Kidney Cancer	CCLE	VHSSS	DEG_SPOP_SBC_1	0.1944
p.P710L	ACH-001100		CCLE	VHSSS	DEG_SPOP_SBC_1	0.25
p.V727L	NCI-H460	lung	COSMIC	VHSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons