DegronMD

Uniprot ID: O15265

Source protein: Ataxin-7

Source gene: ATXN7

Class: DEG_SPOP_SBC_1

Location: 715:719

E3 ligase: SPOP

DEGRON score: 0.9841

ASA_SCORE: 93.78

COIL: 0.9332

CONS_SCORE: 0.2981

DSS_SCORE: 0.6033

HELIX: 0.0296

FCONS_SCORE: 0.7658

RIG_SCORE: 0.5881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R707H	TCGA-VQ-A8P2	STAD	TCGA	VHSSS	DEG_SPOP_SBC_1	0.1111
p.R707H	DO233624	GACA	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1111
p.R707H	DO51761	STAD	ICGC	VHSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14544	Suppressor of cytokine signaling 6	DEG_SPOP_SBC_1	159:163	VHSSS	SPOP	0.9987	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	715:719	VHSSS	SPOP	0.9841	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	713:717	VHSSS	SPOP	0.5994	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	99:103	VHSSS	SPOP	0.9941	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	231:235	VHSSS	SPOP	0.7399	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	41:45	VHSSS	SPOP	0.9419	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1375:1379	VHSSS	SPOP	0.7433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons