DegronMD

Uniprot ID: Q8N5C8

Source protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Source gene: TAB3

Class: DEG_SCF_FBW7_1

Location: 437:444

E3 ligase: FBXW7

DEGRON score: 0.996

ASA_SCORE: 89.35

COIL: 0.9723

CONS_SCORE: 0.4668

DSS_SCORE: 0.5923

HELIX: 0.01

FCONS_SCORE: 1.0783

RIG_SCORE: 0.6319

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P437T	DO225192	BRCA	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	0.7031
p.Q433L	DO223019	ESCA	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	0.2222
p.P449T	DO229022	LICA	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	0.1944
p.V427M	DO52666	MALY	ICGC	PSCTPSPS	DEG_SCF_FBW7_1	0.0556
p.T440A	SIDM00845	Burkitt's Lymphoma	GDSC	PSCTPSPS	DEG_SCF_FBW7_1	0.825
p.T440A	SIDM01519	Head and Neck Carcinoma	GDSC	PSCTPSPS	DEG_SCF_FBW7_1	0.825
p.T440A	ACH-000786	Lymphoma	CCLE	PSCTPSPS	DEG_SCF_FBW7_1	0.825
p.T440A	ACH-000992	Head and Neck Cancer	CCLE	PSCTPSPS	DEG_SCF_FBW7_1	0.825
p.T440A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSCTPSPS	DEG_SCF_FBW7_1	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SCF_FBW7_1	437:444	PSCTPSPS	FBXW7	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons