DegronMD

Uniprot ID: Q9C0I3

Source protein: Serine-rich coiled-coil domain-containing protein 1

Source gene: CCSER1

Class: LIG_APCC_ABBA_1

Location: 447:452

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9175

ASA_SCORE: 84.5833

COIL: 0.725

CONS_SCORE: 0.7566

DSS_SCORE: 0.3406

HELIX: 0.229

FCONS_SCORE: 1.202

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R451H	TCGA-B5-A11E	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	0.7133
p.R451H	DO41644	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	0.7133
p.R461Q	TCGA-E6-A1LX	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	0.0833
p.R461Q	TCGA-EO-A3B0	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	0.0833
p.R461Q	DO219773	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	0.0833
p.R461Q	DO41020	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	0.0833
p.R451C	TCGA-EO-A22U	UCEC	TCGA	LSPFRE	LIG_APCC_ABBA_1	0.719
p.R451C	DO43755	UCEC	ICGC	LSPFRE	LIG_APCC_ABBA_1	0.719
p.A440S	DO228985	LICA	ICGC	LSPFRE	LIG_APCC_ABBA_1	0.1389
p.A437T	DO232761	PBCA	ICGC	LSPFRE	LIG_APCC_ABBA_1	0.0556
p.I456V	SIDM00425	Ovarian Carcinoma	GDSC	LSPFRE	LIG_APCC_ABBA_1	0.2222
p.I456V	ACH-000663	Ovarian Cancer	CCLE	LSPFRE	LIG_APCC_ABBA_1	0.2222
p.I456V	OVTOKO	ovary	COSMIC	LSPFRE	LIG_APCC_ABBA_1	0.2222
p.E457D	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LSPFRE	LIG_APCC_ABBA_1	0.1944
p.E457D	ACH-000953	Leukemia	CCLE	LSPFRE	LIG_APCC_ABBA_1	0.1944
p.E457D	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LSPFRE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	LIG_APCC_ABBA_1	447:452	LSPFRE	APC,CDC20,FZR1	0.9175	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons