DegronMD

Uniprot ID: Q9C0I3

Source protein: Serine-rich coiled-coil domain-containing protein 1

Source gene: CCSER1

Class: DEG_SCF_FBW7_1

Location: 62:69

E3 ligase: FBXW7

DEGRON score: 0.9717

ASA_SCORE: 84

COIL: 0.8009

CONS_SCORE: 0.746

DSS_SCORE: 0.6867

HELIX: 0.0216

FCONS_SCORE: 1.04

RIG_SCORE: 0.6519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R64H	TCGA-2W-A8YY	CESC	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.7133
p.R64H	TCGA-D1-A167	UCEC	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.7133
p.R64H	TCGA-DU-A76L	LGG	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.7133
p.R64H	DO223732	CESC	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.7133
p.R64H	DO50151	LGG	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.7133
p.R64H	DO40978	UCEC	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.7133
p.R59Q	TCGA-A6-3808	COAD	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.R59Q	TCGA-EE-A20C	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.R59Q	DO8408	COAD	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.R59Q	DO47665	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.G57C	TCGA-BF-A1Q0	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.1944
p.G57C	DO47374	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.1944
p.H72Q	TCGA-CV-A45Z	HNSC	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.H72Q	DO52064	HNSC	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.S69T	TCGA-ER-A2NC	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.6005
p.S69T	DO47318	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.6005
p.R64C	TCGA-YG-AA3N	SKCM	TCGA	IFRTPSIS	DEG_SCF_FBW7_1	0.719
p.R64C	DO220899	MELA	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.719
p.R64C	DO51298	SKCM	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.719
p.K79Q	DO234210	ESAD	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.1667
p.H71N	DO50851	LIRI	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.2778
p.R59H	DO222775	MELA	ICGC	IFRTPSIS	DEG_SCF_FBW7_1	0.25
p.S61T	SIDM00876	Non-Cancerous	GDSC	IFRTPSIS	DEG_SCF_FBW7_1	0.3056
p.S61T	SIDM00877	Breast Carcinoma	GDSC	IFRTPSIS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SCF_FBW7_1	62:69	IFRTPSIS	FBXW7	0.9717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons