DegronMD - Q8IWZ8(SUGP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A360V	TCGA-56-8305	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2778
p.A360V	DO223725	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2778
p.P365H	TCGA-66-2734	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.P365H	DO26430	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.P365S	TCGA-90-A4ED	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.P365S	DO45482	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.A105T	TCGA-D5-6930	COAD	TCGA	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1111
p.A105T	TCGA-D5-6930	COAD	TCGA	AQTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.Q97R	DO222805	BTCA	ICGC	AQTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.A112T	DO227549	COCA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.3056
p.A112T	DO227549	COCA	ICGC	AQTST	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.A121T	DO227657	COCA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.3056
p.T358M	DO222737	COCA	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.S125Y	DO229015	LICA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1944
p.S115R	DO229045	LICA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.7427
p.A121S	DO23222	LINC	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.3056
p.P361S	DO48715	LIRI	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.25
p.P367A	DO230961	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.P367A	DO224594	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.A99P	DO224563	LUSC	ICGC	AQTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6392
p.P117S	DO229257	THCA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6752
p.A99V	SIDM02050	Colorectal Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.5825
p.S125T	SIDM00333	Endometrial Carcinoma	GDSC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1944
p.S125T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1944
p.S125T	MFE-319	endometrium	COSMIC	PPSTPTPS	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1944
p.P349S	SIDM00003	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.P349S	M14	skin	COSMIC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.A350G	SIDM01412	Oral Cavity Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2222
p.A350G	ACH-000762	Head and Neck Cancer	CCLE	PASST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUGP1

UniProt ID: Q8IWZ8

Entrez ID: 57794

Protein name: SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUGP1 in