DegronMD

Uniprot ID: Q8IWZ8

Source protein: SURP and G-patch domain-containing protein 1

Source gene: SUGP1

Class: DEG_SPOP_SBC_1

Location: 99:103

E3 ligase: SPOP

DEGRON score: 0.8773

ASA_SCORE: 89.5

COIL: 0.7418

CONS_SCORE: 0.335

DSS_SCORE: 0.5983

HELIX: 0.2538

FCONS_SCORE: 0.6772

RIG_SCORE: 0.6553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A105T	TCGA-D5-6930	COAD	TCGA	AQTST	DEG_SPOP_SBC_1	0.2778
p.Q97R	DO222805	BTCA	ICGC	AQTST	DEG_SPOP_SBC_1	0.2778
p.A112T	DO227549	COCA	ICGC	AQTST	DEG_SPOP_SBC_1	0.0833
p.A99P	DO224563	LUSC	ICGC	AQTST	DEG_SPOP_SBC_1	0.6392
p.A99V	SIDM02050	Colorectal Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1175:1179	AQTST	SPOP	0.9904	More...
Q8IWZ8	SURP and G-patch domain-containing protein 1	DEG_SPOP_SBC_1	99:103	AQTST	SPOP	0.8773	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	85:89	AQTST	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons