DegronMD

Uniprot ID: Q8IZF5

Source protein: Adhesion G-protein coupled receptor F3

Source gene: ADGRF3

Class: DEG_SPOP_SBC_1

Location: 85:89

E3 ligase: SPOP

DEGRON score: 0.8742

ASA_SCORE: 59.46

COIL: 0.589

CONS_SCORE: 0.1979

DSS_SCORE: 0.5711

HELIX: 0.153

FCONS_SCORE: 1.0334

RIG_SCORE: 0.8021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G80R	SIDM00623	Other Blood Cancers	GDSC	AQTST	DEG_SPOP_SBC_1	0.1944
p.G80R	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	AQTST	DEG_SPOP_SBC_1	0.1944
p.R76Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	0.0833
p.R76Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	0.0833
p.R76Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	0.0833
p.R76Q	KYSE-510	oesophagus	COSMIC	AQTST	DEG_SPOP_SBC_1	0.0833
p.R76Q	NCI-H1651	lung	COSMIC	AQTST	DEG_SPOP_SBC_1	0.0833
p.R76Q	DMS-53	lung	COSMIC	AQTST	DEG_SPOP_SBC_1	0.0833
p.Q81K	SIDM00256	Neuroblastoma	GDSC	AQTST	DEG_SPOP_SBC_1	0.2222
p.Q81K	NB14	autonomic_ganglia	COSMIC	AQTST	DEG_SPOP_SBC_1	0.2222
p.T77P	NB5	autonomic_ganglia	COSMIC	AQTST	DEG_SPOP_SBC_1	0.1111
p.T87P	NB5	autonomic_ganglia	COSMIC	AQTST	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1175:1179	AQTST	SPOP	0.9904	More...
Q8IWZ8	SURP and G-patch domain-containing protein 1	DEG_SPOP_SBC_1	99:103	AQTST	SPOP	0.8773	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	85:89	AQTST	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons