DegronMD - Q8IZF5(ADGRF3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P69S	SIDM01151	Hepatocellular Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.6752
p.P69S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.6752
p.P69S	SIDM00241	Breast Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.6752
p.P69S	SIDM00302	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.6752
p.G80R	SIDM00623	Other Blood Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.G80R	SIDM00623	Other Blood Cancers	GDSC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1944
p.G80R	Mo-T	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.G80R	Mo-T	haematopoietic and lymphoid tissue	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1944
p.R76Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.R76Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.R76Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.R76Q	KYSE-510	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76Q	KYSE-510	oesophagus	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.R76Q	NCI-H1651	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76Q	NCI-H1651	lung	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.R76Q	DMS-53	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76Q	DMS-53	lung	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.0833
p.Q81K	SIDM00256	Neuroblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.Q81K	SIDM00256	Neuroblastoma	GDSC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.Q81K	NB14	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.Q81K	NB14	autonomic ganglia	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.2222
p.T146P	NB5	autonomic ganglia	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	156:164	Mutation blocking phosphorylation signal	0.5
p.A169V	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1944
p.T77P	NB5	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.2222
p.T77P	NB5	autonomic ganglia	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation rewiring degron network	0.1111
p.A166T	NCI-H345	lung	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.2778
p.G174V	Farage	haematopoietic and lymphoid tissue	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	156:164	Mutation substituting flanking lysine	0.1667
p.T150P	SK-GT-4	oesophagus	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1667
p.P155S	NCI-H522	lung	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.T87P	NB5	autonomic ganglia	COSMIC	AQTST	DEG_SPOP_SBC_1	85:89	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRF3

UniProt ID: Q8IZF5

Entrez ID: 165082

Protein name: Adhesion G-protein coupled receptor F3 (G-protein coupled receptor 113) (G-protein coupled receptor PGR23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRF3 in