DegronMD

Uniprot ID: Q8IZF5

Source protein: Adhesion G-protein coupled receptor F3

Source gene: ADGRF3

Class: DEG_APCC_DBOX_1

Location: 156:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.756

ASA_SCORE: 63.7

COIL: 0.5206

CONS_SCORE: 0.3053

DSS_SCORE: 0.3089

HELIX: 0.0281

FCONS_SCORE: 0.8317

RIG_SCORE: 0.7405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T146P	NB5	autonomic_ganglia	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	0.5
p.A169V	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	0.1944
p.A166T	NCI-H345	lung	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	0.2778
p.G174V	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	0.1667
p.T150P	SK-GT-4	oesophagus	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	0.1667
p.P155S	NCI-H522	lung	COSMIC	PRPLLTGLR	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_APCC_DBOX_1	156:164	PRPLLTGLR	APC,CDC20,FZR1	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons