DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 1175:1179

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 81.58

COIL: 0.8792

CONS_SCORE: 0.3645

DSS_SCORE: 0.4681

HELIX: 0.0612

FCONS_SCORE: 0.9232

RIG_SCORE: 0.7159

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1167T	TCGA-AP-A059	UCEC	TCGA	AQTST	DEG_SPOP_SBC_1	0.1111
p.A1167T	DO41361	UCEC	ICGC	AQTST	DEG_SPOP_SBC_1	0.1111
p.A1169V	TCGA-CG-5721	STAD	TCGA	AQTST	DEG_SPOP_SBC_1	0.1667
p.A1169V	DO233261	GACA	ICGC	AQTST	DEG_SPOP_SBC_1	0.1667
p.A1169V	DO38192	STAD	ICGC	AQTST	DEG_SPOP_SBC_1	0.1667
p.A1181D	DO228974	LICA	ICGC	AQTST	DEG_SPOP_SBC_1	0.2778
p.A1181D	DO229038	LICA	ICGC	AQTST	DEG_SPOP_SBC_1	0.2778
p.Q1165K	DO229032	LICA	ICGC	AQTST	DEG_SPOP_SBC_1	0.0556
p.F1171I	DO221547	PACA	ICGC	AQTST	DEG_SPOP_SBC_1	0.2222
p.A1172V	DO229117	PRAD	ICGC	AQTST	DEG_SPOP_SBC_1	0.25
p.A1172S	DO229117	PRAD	ICGC	AQTST	DEG_SPOP_SBC_1	0.25
p.G1184C	ACH-000997	Colon/Colorectal Cancer	CCLE	AQTST	DEG_SPOP_SBC_1	0.1944
p.G1184C	ACH-001061	Colon/Colorectal Cancer	CCLE	AQTST	DEG_SPOP_SBC_1	0.1944
p.G1184C	ACH-001091	Colon/Colorectal Cancer	CCLE	AQTST	DEG_SPOP_SBC_1	0.1944
p.G1184C	HCT-15	large_intestine	COSMIC	AQTST	DEG_SPOP_SBC_1	0.1944
p.V1185E	NCI-H1048	lung	COSMIC	AQTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1175:1179	AQTST	SPOP	0.9904	More...
Q8IWZ8	SURP and G-patch domain-containing protein 1	DEG_SPOP_SBC_1	99:103	AQTST	SPOP	0.8773	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	85:89	AQTST	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons