DegronMD

Uniprot ID: Q8IWZ8

Source protein: SURP and G-patch domain-containing protein 1

Source gene: SUGP1

Class: DEG_SCF_FBW7_1

Location: 113:120

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 80.525

COIL: 0.9411

CONS_SCORE: 0.4167

DSS_SCORE: 0.764

HELIX: 0.0271

FCONS_SCORE: 1.0935

RIG_SCORE: 0.5557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A105T	TCGA-D5-6930	COAD	TCGA	PPSTPTPS	DEG_SCF_FBW7_1	0.1111
p.A112T	DO227549	COCA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	0.3056
p.A121T	DO227657	COCA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	0.3056
p.S125Y	DO229015	LICA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	0.1944
p.S115R	DO229045	LICA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	0.7427
p.A121S	DO23222	LINC	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	0.3056
p.P117S	DO229257	THCA	ICGC	PPSTPTPS	DEG_SCF_FBW7_1	0.6752
p.S125T	SIDM00333	Endometrial Carcinoma	GDSC	PPSTPTPS	DEG_SCF_FBW7_1	0.1944
p.S125T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPSTPTPS	DEG_SCF_FBW7_1	0.1944
p.S125T	MFE-319	endometrium	COSMIC	PPSTPTPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ8	SURP and G-patch domain-containing protein 1	DEG_SCF_FBW7_1	113:120	PPSTPTPS	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons