DegronMD - Q9H0C8(ILKAP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F48L	TCGA-24-1413	OV	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.0556
p.F48L	TCGA-24-1413	OV	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0556
p.F48L	DO31310	OV	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.0556
p.F48L	DO31310	OV	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.0556
p.L27R	TCGA-AC-A23H	BRCA	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389
p.L27R	DO2401	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389
p.P33H	TCGA-AJ-A3OJ	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.3056
p.P33H	DO42753	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.3056
p.S61Y	TCGA-AX-A0J0	UCEC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6009
p.S61Y	TCGA-BS-A0UV	UCEC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6009
p.S61Y	TCGA-DU-6392	LGG	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6009
p.S61Y	DO22237	LGG	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6009
p.S61Y	DO41133	UCEC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6009
p.S61Y	DO42793	UCEC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6009
p.D58N	TCGA-B2-4098	KIRC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6932
p.D58N	DO19573	KIRC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6932
p.P45S	TCGA-B2-5639	KIRC	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389
p.P45S	DO19803	KIRC	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389
p.A35T	TCGA-D1-A101	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation altering degron motif	0.6028
p.A35T	DO43955	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation altering degron motif	0.6028
p.G74E	TCGA-DX-A8BP	SARC	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.0556
p.G74E	DO220056	SARC	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.0556
p.P33S	TCGA-EE-A181	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.3056
p.P33S	DO37444	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.3056
p.G44E	TCGA-FR-A726	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1667
p.G44E	DO48665	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1667
p.P45H	TCGA-HU-A4H8	STAD	TCGA	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389
p.P45H	DO47869	STAD	ICGC	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389
p.A54T	TCGA-VQ-A8P2	STAD	TCGA	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.A54T	DO51761	STAD	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.A54T	SIDM01018	Hodgkin's Lymphoma	GDSC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.A54T	ACH-000815	Lymphoma	CCLE	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.A54T	KM-H2	haematopoietic and lymphoid tissue	COSMIC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.G57D	DO233767	GACA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.3056
p.P52Q	DO229018	LICA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.1667
p.A63D	DO229027	LICA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6682
p.A63D	DO229031	LICA	ICGC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.6682
p.P10H	DO229299	LMS	ICGC	MDLFGD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2222
p.D58Y	SIDM00120	Prostate Carcinoma	GDSC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7325
p.D58Y	ACH-000979	Prostate Cancer	CCLE	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7325
p.D58Y	DU-145	prostate	COSMIC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7325
p.A54V	SIDM00901	Endometrial Carcinoma	GDSC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.A54V	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.A54V	AN3-CA	endometrium	COSMIC	DSGSLAT	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2222
p.L27M	ACH-000499	Bone Cancer	CCLE	PASST	DEG_SPOP_SBC_1	34:38	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ILKAP

UniProt ID: Q9H0C8

Entrez ID: 80895

Protein name: Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ILKAP in