DegronMD

Uniprot ID: Q9H0C8

Source protein: Integrin-linked kinase-associated serine/threonine phosphatase 2C

Source gene: ILKAP

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 76.6333

COIL: 0.8488

CONS_SCORE: 0.4135

DSS_SCORE: 0.9467

HELIX: 0.0703

FCONS_SCORE: 1.153

RIG_SCORE: 0.7156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10H	DO229299	LMS	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98082	Disabled homolog 2	LIG_APCC_ABBA_1	213:218	MDLFGD	APC,CDC20,FZR1	0.996	More...
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	LIG_APCC_ABBA_1	1:6	MDLFGD	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons