DegronMD

Uniprot ID: P98082

Source protein: Disabled homolog 2

Source gene: DAB2

Class: LIG_APCC_ABBA_1

Location: 213:218

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 77.7667

COIL: 0.6898

CONS_SCORE: 0.637

DSS_SCORE: 0.5497

HELIX: 0.1903

FCONS_SCORE: 1.0984

RIG_SCORE: 0.74

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S208L	TCGA-19-5956	GBM	TCGA	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	TCGA-E6-A1LX	UCEC	TCGA	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	TCGA-F1-6874	STAD	TCGA	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	DO224569	BRCA	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	DO1005	BRCA	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	DO13863	GBM	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	DO38201	STAD	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	DO41020	UCEC	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.S208L	SIDM01611	Endometrial Carcinoma	GDSC	MDLFGD	LIG_APCC_ABBA_1	0.6389
p.L206M	DO228971	LICA	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.1389
p.D218E	DO229035	LICA	ICGC	MDLFGD	LIG_APCC_ABBA_1	0.5647
p.N226S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	MDLFGD	LIG_APCC_ABBA_1	0.1111
p.N226S	KYSE-50	oesophagus	COSMIC	MDLFGD	LIG_APCC_ABBA_1	0.1111
p.S228Y	OVK-18	ovary	COSMIC	MDLFGD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98082	Disabled homolog 2	LIG_APCC_ABBA_1	213:218	MDLFGD	APC,CDC20,FZR1	0.996	More...
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	LIG_APCC_ABBA_1	1:6	MDLFGD	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons