DegronMD - P98082(DAB2)

FUNCTION: Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. View more >>

GO - Biological processes (BP): apoptotic process [GO:0006915]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to transforming growth factor beta stimulus [GO:0071560]; clathrin coat assembly [GO:0048268]; leading edge cell differentiation [GO:0035026]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cell migration [GO:0030335]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of endocytosis [GO:0045807]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]; response to salt [GO:1902074]; response to steroid hormone [GO:0048545]; Wnt signaling pathway [GO:0016055] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S369L	TCGA-06-5416	GBM	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7667
p.S369L	TCGA-A5-A0GP	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7667
p.S369L	TCGA-AX-A0J0	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7667
p.S369L	DO10880	GBM	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7667
p.S369L	DO41109	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7667
p.S369L	DO41133	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7667
p.G591W	TCGA-17-Z031	LUAD	TCGA	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.G591W	TCGA-17-Z031	LUAD	TCGA	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2222
p.L265I	TCGA-17-Z031	LUAD	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.3056
p.L265I	SIDM00146	Breast Carcinoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.3056
p.L265I	ACH-000768	Breast Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.3056
p.L265I	MDA-MB-231	breast	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.3056
p.S313Y	TCGA-19-5956	GBM	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S313Y	TCGA-EO-A22U	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S313Y	DO13863	GBM	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S313Y	DO43755	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S208L	TCGA-19-5956	GBM	TCGA	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	TCGA-E6-A1LX	UCEC	TCGA	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	TCGA-F1-6874	STAD	TCGA	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	DO224569	BRCA	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	DO1005	BRCA	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	DO13863	GBM	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	DO38201	STAD	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	DO41020	UCEC	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.S208L	SIDM01611	Endometrial Carcinoma	GDSC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation blocking phosphorylation signal	0.6389
p.C263S	TCGA-44-A4SS	LUAD	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.C263S	DO24227	LUAD	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.S328C	TCGA-55-6969	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.S328C	DO24586	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.W584L	TCGA-60-2711	LUSC	TCGA	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.5904
p.S332I	TCGA-66-2742	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5556
p.S332I	DO26439	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5556
p.A580V	TCGA-78-7535	LUAD	TCGA	GPSASVAPN	DEG_SIAH_1	574:582	Mutation altering degron motif	0.5825
p.P373S	TCGA-94-8491	LUSC	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P373S	DO219174	LUSC	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.T269M	TCGA-A5-A2K3	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7423
p.T269M	TCGA-E6-A2P8	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7423
p.T269M	DO40924	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7423
p.T269M	DO43899	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7423
p.S264Y	TCGA-A5-A2K5	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation blocking phosphorylation signal	0.7222
p.S264Y	DO41379	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation blocking phosphorylation signal	0.7222
p.A577T	TCGA-A7-A0CJ	BRCA	TCGA	GPSASVAPN	DEG_SIAH_1	574:582	Mutation altering degron motif	0.7139
p.P266S	TCGA-AP-A056	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.6752
p.P266S	DO43971	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.6752
p.S316Y	TCGA-AX-A2HC	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.S316Y	DO41572	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.R376I	TCGA-B5-A1MR	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1389
p.R376I	DO41758	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1389
p.P373Q	TCGA-BF-A1PU	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P373Q	DO50278	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P373Q	SIDM00845	Burkitt's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P373Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.P266A	TCGA-BH-A1F0	BRCA	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7503
p.P266A	DO1491	BRCA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7503
p.A583V	TCGA-BR-A4CR	STAD	TCGA	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.5825
p.T586A	TCGA-CG-5721	STAD	TCGA	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.7139
p.S324L	TCGA-DU-6392	LGG	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.7667
p.S324L	TCGA-IB-7651	PAAD	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.7667
p.S324L	DO22237	LGG	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.7667
p.S324L	DO46657	PAAD	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.7667
p.F366L	TCGA-DX-A48L	SARC	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.587
p.F366L	DO219985	SARC	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.587
p.P568S	TCGA-E2-A108	BRCA	TCGA	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.1667
p.S327L	TCGA-E6-A1LX	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.25
p.S327L	DO41020	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.25
p.G334E	TCGA-EB-A51B	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.G334E	DO47343	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S313F	TCGA-EE-A2MP	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S313F	DO50450	ESAD	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S313F	DO37818	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.T565A	TCGA-F5-6863	READ	TCGA	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.P575S	TCGA-FW-A3R5	SKCM	TCGA	GPSASVAPN	DEG_SIAH_1	574:582	Mutation altering degron motif	0.6752
p.P363Q	TCGA-GN-A265	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.P363Q	DO37491	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.E277Q	TCGA-S5-AA26	BLCA	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.E277Q	DO51904	BLCA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.2222
p.S313C	TCGA-XF-A9SG	BLCA	TCGA	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S313C	DO51912	BLCA	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.5833
p.S593C	DO219055	BLCA	ICGC	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1667
p.A359T	DO2874	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1667
p.S310L	DO10172	COAD	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S310L	DO222504	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S310L	SIDM00781	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S310L	SIDM00780	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S310L	ACH-000967	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S310L	ACH-001199	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S310L	SNU-C2B	large intestine	COSMIC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.M590I	DO9594	COAD	ICGC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.1111
p.M590I	DO9594	COAD	ICGC	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.25
p.A374T	DO234209	ESAD	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1944
p.I260V	DO223072	ESCA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1667
p.P270H	DO233792	GACA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7694
p.V375A	DO233884	GACA	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1667
p.L206M	DO228971	LICA	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1389
p.P268Q	DO229034	LICA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.5924
p.P268Q	DO229006	LICA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.5924
p.D218E	DO229035	LICA	ICGC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation altering degron motif	0.5647
p.T565I	DO229047	LICA	ICGC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM01020	Plasma Cell Myeloma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM00961	Ewing's Sarcoma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM01471	Chronic Myelogenous Leukemia	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	SIDM01473	Plasma Cell Myeloma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	KYSE-180	oesophagus	COSMIC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	TE-10	oesophagus	COSMIC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	TE-11	oesophagus	COSMIC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.T565I	CADO-ES1	bone	COSMIC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.0833
p.A362V	DO24860	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.25
p.G259R	DO224541	LUSC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1389
p.G259R	DO231003	LUSC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1389
p.W366L	DO26987	LUSC	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7015
p.P325L	DO222595	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.75
p.M315I	DO37412	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking ubiquitination signal	0.6389
p.A365V	DO47843	STAD	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.6936
p.M590T	DO38232	STAD	ICGC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.1111
p.M590T	DO38232	STAD	ICGC	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.25
p.T368A	DO38192	STAD	ICGC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7139
p.P265S	DO43434	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.3056
p.A310T	DO42280	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0556
p.S331R	DO52402	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1389
p.F578C	DO41379	UCEC	ICGC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation altering degron motif	0.7108
p.W364R	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.W364R	SIDM00234	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.W364R	SIDM01061	Oral Cavity Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.W364R	SIDM01569	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.P330S	SIDM01649	Non-Cancerous	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1667
p.P330S	SIDM00184	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1667
p.P330S	ACH-002355	Non-Cancerous	CCLE	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1667
p.S328F	SIDM00545	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.S328F	ACH-000987	Skin Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.S328F	Mewo	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.6667
p.K315T	SIDM00845	Burkitt's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking ubiquitination signal	0.6389
p.T587A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.7139
p.C263F	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.C263F	ACH-000666	Lung Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.C263F	NCI-H1355	lung	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.25
p.N226S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.N226S	KYSE-50	oesophagus	COSMIC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.A272P	SIDM00050	Chondrosarcoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.6392
p.A272P	ACH-002093	Bone Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.6392
p.A272P	CHSA0108	bone	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.6392
p.V572A	SIDM00807	Bladder Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.2778
p.V572A	5637	urinary tract	COSMIC	GPSASVAPN	DEG_SIAH_1	574:582	Mutation rewiring degron network	0.2778
p.E322D	SIDM00118	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.6758
p.E322D	ACH-001081	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.6758
p.E322D	HCC2998	large intestine	COSMIC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.6758
p.T269K	SIDM01318	Hepatocellular Carcinoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7306
p.T269K	ACH-001318	Liver Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation altering degron motif	0.7306
p.P593T	ACH-000975	Lung Cancer	CCLE	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1667
p.F311L	ACH-000982	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0833
p.G259C	ACH-001991	Primary	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1389
p.Q281H	LAN-6	autonomic ganglia	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.S228Y	OVK-18	ovary	COSMIC	MDLFGD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.0556
p.V370A	DIFI	large intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.T585I	SNU-C1	large intestine	COSMIC	AWSTT	DEG_SPOP_SBC_1	583:587	Mutation altering degron motif	0.7078
p.N264T	IHH-4	thyroid	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	266:273	Mutation blocking phosphorylation signal	0.7222
p.N331D	MC-1010	haematopoietic and lymphoid tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1389
p.V360L	NCI-H510A	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1944
p.S361F	CP66-MEL	skin	COSMIC	PFSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2222
p.S323R	NCI-H1417	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.7427
p.V326L	TGW	autonomic ganglia	COSMIC	KKENS	DEG_APCC_KENBOX_2	320:324	Mutation blocking phosphorylation signal	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAB2

UniProt ID: P98082

Entrez ID: 1601

Protein name: Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DAB2 in