DegronMD

Uniprot ID: P98082

Source protein: Disabled homolog 2

Source gene: DAB2

Class: DEG_SPOP_SBC_1

Location: 583:587

E3 ligase: SPOP

DEGRON score: 0.9951

ASA_SCORE: 78.54

COIL: 0.924

CONS_SCORE: 0.4941

DSS_SCORE: 0.4565

HELIX: 0.0504

FCONS_SCORE: 0.9246

RIG_SCORE: 0.708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G591W	TCGA-17-Z031	LUAD	TCGA	AWSTT	DEG_SPOP_SBC_1	0.2222
p.W584L	TCGA-60-2711	LUSC	TCGA	AWSTT	DEG_SPOP_SBC_1	0.5904
p.A583V	TCGA-BR-A4CR	STAD	TCGA	AWSTT	DEG_SPOP_SBC_1	0.5825
p.T586A	TCGA-CG-5721	STAD	TCGA	AWSTT	DEG_SPOP_SBC_1	0.7139
p.S593C	DO219055	BLCA	ICGC	AWSTT	DEG_SPOP_SBC_1	0.1667
p.M590I	DO9594	COAD	ICGC	AWSTT	DEG_SPOP_SBC_1	0.25
p.M590T	DO38232	STAD	ICGC	AWSTT	DEG_SPOP_SBC_1	0.25
p.T587A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AWSTT	DEG_SPOP_SBC_1	0.7139
p.P593T	ACH-000975	Lung Cancer	CCLE	AWSTT	DEG_SPOP_SBC_1	0.1667
p.T585I	SNU-C1	large_intestine	COSMIC	AWSTT	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	583:587	AWSTT	SPOP	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons