DegronMD

Uniprot ID: P98082

Source protein: Disabled homolog 2

Source gene: DAB2

Class: DEG_SIAH_1

Location: 574:582

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9559

ASA_SCORE: 69.3889

COIL: 0.8978

CONS_SCORE: 0.5418

DSS_SCORE: 0.3739

HELIX: 0.0794

FCONS_SCORE: 0.9882

RIG_SCORE: 0.6935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G591W	TCGA-17-Z031	LUAD	TCGA	GPSASVAPN	DEG_SIAH_1	0.0833
p.A580V	TCGA-78-7535	LUAD	TCGA	GPSASVAPN	DEG_SIAH_1	0.5825
p.A577T	TCGA-A7-A0CJ	BRCA	TCGA	GPSASVAPN	DEG_SIAH_1	0.7139
p.P568S	TCGA-E2-A108	BRCA	TCGA	GPSASVAPN	DEG_SIAH_1	0.1667
p.T565A	TCGA-F5-6863	READ	TCGA	GPSASVAPN	DEG_SIAH_1	0.0833
p.P575S	TCGA-FW-A3R5	SKCM	TCGA	GPSASVAPN	DEG_SIAH_1	0.6752
p.M590I	DO9594	COAD	ICGC	GPSASVAPN	DEG_SIAH_1	0.1111
p.T565I	DO229047	LICA	ICGC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM01020	Plasma Cell Myeloma	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM00961	Ewing's Sarcoma	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM01471	Chronic Myelogenous Leukemia	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	SIDM01473	Plasma Cell Myeloma	GDSC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	KYSE-180	oesophagus	COSMIC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	TE-10	oesophagus	COSMIC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	TE-11	oesophagus	COSMIC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	GPSASVAPN	DEG_SIAH_1	0.0833
p.T565I	CADO-ES1	bone	COSMIC	GPSASVAPN	DEG_SIAH_1	0.0833
p.M590T	DO38232	STAD	ICGC	GPSASVAPN	DEG_SIAH_1	0.1111
p.F578C	DO41379	UCEC	ICGC	GPSASVAPN	DEG_SIAH_1	0.7108
p.V572A	SIDM00807	Bladder Carcinoma	GDSC	GPSASVAPN	DEG_SIAH_1	0.2778
p.V572A	5637	urinary_tract	COSMIC	GPSASVAPN	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98082	Disabled homolog 2	DEG_SIAH_1	574:582	GPSASVAPN	SIAH1,SIAH2,SIAH3	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons