DegronMD

Uniprot ID: P98082

Source protein: Disabled homolog 2

Source gene: DAB2

Class: DEG_SCF_FBW7_1

Location: 266:273

E3 ligase: FBXW7

DEGRON score: 0.7333

ASA_SCORE: 86.1

COIL: 0.8936

CONS_SCORE: 0.4832

DSS_SCORE: 0.4879

HELIX: 0.0758

FCONS_SCORE: 0.9869

RIG_SCORE: 0.6847

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L265I	TCGA-17-Z031	LUAD	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.3056
p.L265I	SIDM00146	Breast Carcinoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	0.3056
p.L265I	ACH-000768	Breast Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	0.3056
p.L265I	MDA-MB-231	breast	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	0.3056
p.C263S	TCGA-44-A4SS	LUAD	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.25
p.C263S	DO24227	LUAD	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.25
p.T269M	TCGA-A5-A2K3	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.7423
p.T269M	TCGA-E6-A2P8	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.7423
p.T269M	DO40924	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.7423
p.T269M	DO43899	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.7423
p.S264Y	TCGA-A5-A2K5	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.7222
p.S264Y	DO41379	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.7222
p.P266S	TCGA-AP-A056	UCEC	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.6752
p.P266S	DO43971	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.6752
p.P266A	TCGA-BH-A1F0	BRCA	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.7503
p.P266A	DO1491	BRCA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.7503
p.E277Q	TCGA-S5-AA26	BLCA	TCGA	PRPTPQAS	DEG_SCF_FBW7_1	0.2222
p.E277Q	DO51904	BLCA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.2222
p.I260V	DO223072	ESCA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.1667
p.P270H	DO233792	GACA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.7694
p.P268Q	DO229034	LICA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.5924
p.P268Q	DO229006	LICA	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.5924
p.G259R	DO224541	LUSC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.1389
p.G259R	DO231003	LUSC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.1389
p.P265S	DO43434	UCEC	ICGC	PRPTPQAS	DEG_SCF_FBW7_1	0.3056
p.C263F	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	0.25
p.C263F	ACH-000666	Lung Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	0.25
p.C263F	NCI-H1355	lung	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	0.25
p.A272P	SIDM00050	Chondrosarcoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	0.6392
p.A272P	ACH-002093	Bone Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	0.6392
p.A272P	CHSA0108	bone	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	0.6392
p.T269K	SIDM01318	Hepatocellular Carcinoma	GDSC	PRPTPQAS	DEG_SCF_FBW7_1	0.7306
p.T269K	ACH-001318	Liver Cancer	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	0.7306
p.G259C	ACH-001991	Primary	CCLE	PRPTPQAS	DEG_SCF_FBW7_1	0.1389
p.Q281H	LAN-6	autonomic_ganglia	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	0.1111
p.N264T	IHH-4	thyroid	COSMIC	PRPTPQAS	DEG_SCF_FBW7_1	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRPTPQAS

Degron related mutations and impact score

Drug responses associated with DAB2 mutations

All proteins holding degron of PRPTPQAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98082	Disabled homolog 2	DEG_SCF_FBW7_1	266:273	PRPTPQAS	FBXW7	0.7333	More...