DegronMD

Uniprot ID: P98082

Source protein: Disabled homolog 2

Source gene: DAB2

Class: DEG_APCC_KENBOX_2

Location: 320:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6959

ASA_SCORE: 99.84

COIL: 0.8498

CONS_SCORE: 0.4575

DSS_SCORE: 0.7469

HELIX: 0.1192

FCONS_SCORE: 0.9425

RIG_SCORE: 0.5475

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S313Y	TCGA-19-5956	GBM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313Y	TCGA-EO-A22U	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313Y	DO13863	GBM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313Y	DO43755	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S328C	TCGA-55-6969	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.6667
p.S328C	DO24586	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6667
p.S332I	TCGA-66-2742	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.5556
p.S332I	DO26439	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5556
p.S316Y	TCGA-AX-A2HC	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.6667
p.S316Y	DO41572	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6667
p.S324L	TCGA-DU-6392	LGG	TCGA	KKENS	DEG_APCC_KENBOX_2	0.7667
p.S324L	TCGA-IB-7651	PAAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.7667
p.S324L	DO22237	LGG	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7667
p.S324L	DO46657	PAAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7667
p.S327L	TCGA-E6-A1LX	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.25
p.S327L	DO41020	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.25
p.G334E	TCGA-EB-A51B	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0556
p.G334E	DO47343	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S313F	TCGA-EE-A2MP	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313F	DO50450	ESAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313F	DO37818	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313C	TCGA-XF-A9SG	BLCA	TCGA	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S313C	DO51912	BLCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5833
p.S310L	DO10172	COAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S310L	DO222504	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S310L	SIDM00781	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S310L	SIDM00780	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S310L	ACH-000967	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S310L	ACH-001199	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S310L	SNU-C2B	large_intestine	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.P325L	DO222595	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.75
p.M315I	DO37412	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6389
p.A310T	DO42280	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S331R	DO52402	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.P330S	SIDM01649	Non-Cancerous	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.P330S	SIDM00184	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.P330S	ACH-002355	Non-Cancerous	CCLE	KKENS	DEG_APCC_KENBOX_2	0.1667
p.S328F	SIDM00545	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.6667
p.S328F	ACH-000987	Skin Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.6667
p.S328F	Mewo	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.6667
p.K315T	SIDM00845	Burkitt's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.6389
p.E322D	SIDM00118	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.6758
p.E322D	ACH-001081	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.6758
p.E322D	HCC2998	large_intestine	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.6758
p.F311L	ACH-000982	Colon/Colorectal Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.0833
p.N331D	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.S323R	NCI-H1417	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.7427
p.V326L	TGW	autonomic_ganglia	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENS

Degron related mutations and impact score

Drug responses associated with DAB2 mutations

All proteins holding degron of KKENS