DegronMD

Uniprot ID: O00515

Source protein: Ladinin-1

Source gene: LAD1

Class: DEG_APCC_KENBOX_2

Location: 381:385

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9602

ASA_SCORE: 116.74

COIL: 0.9068

CONS_SCORE: 0.4776

DSS_SCORE: 0.6355

HELIX: 0.0832

FCONS_SCORE: 0.8169

RIG_SCORE: 0.6407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R377W	TCGA-55-7227	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2222
p.R391S	TCGA-A3-A6NL	KIRC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1667
p.M378I	TCGA-EE-A2GU	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.25
p.S385L	TCGA-EO-A22X	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.7667
p.R391W	DO24050	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.M392I	DO37639	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.5833
p.R374Q	DO37603	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.R374Q	DO37567	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.R374Q	DO37814	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.R382H	DO41584	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.8244
p.S385P	SIDM00596	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.6752
p.S385P	ACH-001517	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.6752
p.S385P	HEC-1	endometrium	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.6752
p.M395R	Mewo	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons