DegronMD

Uniprot ID: O60242

Source protein: Adhesion G protein-coupled receptor B3

Source gene: ADGRB3

Class: DEG_APCC_KENBOX_2

Location: 1271:1275

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6429

ASA_SCORE: 104.5

COIL: 0.7548

CONS_SCORE: 0.2701

DSS_SCORE: 0.349

HELIX: 0.1838

FCONS_SCORE: 0.922

RIG_SCORE: 0.7422

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1280S	SIDM00506	Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.T1280S	COR-L88	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.E1273K	SIDM00337	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.7022
p.E1273K	MEL-HO	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.7022
p.L1265H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.L1265H	NCI-H650	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.L1277F	SIDM00814	Other Solid Cancers	GDSC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.L1277F	SW13	adrenal_gland	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons