DegronMD

Uniprot ID: P29965

Source protein: CD40 ligand

Source gene: CD40LG

Class: DEG_APCC_KENBOX_2

Location: 106:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7872

ASA_SCORE: 115.06

COIL: 0.6908

CONS_SCORE: 0.4773

DSS_SCORE: 0.5599

HELIX: 0.2896

FCONS_SCORE: 1.1051

RIG_SCORE: 0.7483

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P120T	TCGA-86-8671	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0556
p.P120T	DO24080	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.G116C	TCGA-AA-3861	COAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1667
p.G116C	DO9562	COAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.E112A	TCGA-B5-A11E	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.2778
p.E112A	DO41644	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.S110C	TCGA-D1-A17D	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.643
p.S110C	DO41746	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.643
p.T105M	TCGA-EO-A22R	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.3056
p.T105M	DO42713	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.I98K	DO222473	BTCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.E104K	DO52701	CLLE	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.S110T	DO220898	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6005
p.K96R	DO38404	STAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.M113I	DO229229	THCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.25
p.N101K	DO229248	THCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.I98M	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.I98M	ACH-000510	Lung Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	0.1111
p.I98M	NCI-H1299	lung	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D97G	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.0833
p.D97G	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.0833
p.A120T	MKN28	stomach	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons