DegronMD - O00515(LAD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S123R	TCGA-06-1800	GBM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.7427
p.R377W	TCGA-55-7227	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.2222
p.R391S	TCGA-A3-A6NL	KIRC	TCGA	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1667
p.Q129H	TCGA-A5-A0G2	UCEC	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.A127T	TCGA-B5-A5OC	UCEC	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.3056
p.R461Q	TCGA-BR-4370	STAD	TCGA	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.6218
p.R461Q	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.6218
p.R461Q	SIDM01242	Melanoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.6218
p.R461Q	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.6218
p.E111K	TCGA-D9-A6EA	SKCM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.1389
p.P108S	TCGA-EB-A3XB	SKCM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0556
p.M378I	TCGA-EE-A2GU	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.25
p.E117D	TCGA-EE-A2M5	SKCM	TCGA	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.3056
p.S385L	TCGA-EO-A22X	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.7667
p.G469V	TCGA-FS-A1ZH	SKCM	TCGA	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.2222
p.V115G	DO48392	BLCA	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.25
p.A119E	DO228948	LICA	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.7701
p.R113P	DO218921	LUAD	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.1944
p.R391W	DO24050	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1667
p.M392I	DO37639	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation blocking phosphorylation signal	0.5833
p.R374Q	DO37603	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.R374Q	DO37567	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.R374Q	DO37814	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.R109Q	DO37679	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.P122S	DO37856	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.6752
p.E462K	DO47255	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E462K	DO37766	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E462K	DO50286	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E462K	DO47331	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7022
p.E131D	DO37425	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.1944
p.E125K	DO50290	SKCM	ICGC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.7022
p.R475Q	DO38499	STAD	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.R456H	DO41752	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.R456H	DO41584	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.R382H	DO41584	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.8244
p.E456K	SIDM00336	Melanoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.E456K	ACH-000881	Skin Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.E456K	MEL-JUSO	skin	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.S385P	SIDM00596	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.6752
p.S385P	ACH-001517	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.6752
p.S385P	HEC-1	endometrium	COSMIC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.6752
p.G451C	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.G451C	ACH-000929	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.G451C	NCI-H2110	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.R461W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7523
p.R461W	ACH-000980	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7523
p.R461W	NCI-H1155	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.7523
p.R466K	SIDM00864	Cervical Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.R466K	ACH-001341	Cervical Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.R466K	DoTc2-4510	cervix	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.3056
p.Q452H	SIDM00721	Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0833
p.Q452H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0833
p.S453G	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.S453G	ACH-000077	Lymphoma	CCLE	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1111
p.S460N	SIDM01699	Chondrosarcoma	GDSC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation blocking phosphorylation signal	0.75
p.S460N	ACH-000224	Non-Cancerous	CCLE	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation blocking phosphorylation signal	0.75
p.R119G	ACH-000588	Myeloma	CCLE	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation altering degron motif	0.7568
p.V116G	SNU-407	large intestine	COSMIC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.2778
p.G465C	NCI-H2110	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation altering degron motif	0.76
p.R109W	NCI-H2347	lung	COSMIC	GRNSLSPVQ	DEG_APCC_DBOX_1	118:126	Mutation rewiring degron network	0.0833
p.R475W	NCI-H1155	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.0556
p.E470K	MEL-JUSO	skin	COSMIC	RKENL	DEG_APCC_KENBOX_2	461:465	Mutation rewiring degron network	0.1944
p.M395R	Mewo	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAD1

UniProt ID: O00515

Entrez ID: 3898

Protein name: Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LAD1 in