DegronMD

Uniprot ID: O00515

Source protein: Ladinin-1

Source gene: LAD1

Class: DEG_APCC_KENBOX_2

Location: 461:465

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9951

ASA_SCORE: 106.36

COIL: 0.6436

CONS_SCORE: 0.5657

DSS_SCORE: 0.4829

HELIX: 0.3282

FCONS_SCORE: 1.0695

RIG_SCORE: 0.7139

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R461Q	TCGA-BR-4370	STAD	TCGA	RKENL	DEG_APCC_KENBOX_2	0.6218
p.R461Q	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.6218
p.R461Q	SIDM01242	Melanoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.6218
p.R461Q	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.6218
p.G469V	TCGA-FS-A1ZH	SKCM	TCGA	RKENL	DEG_APCC_KENBOX_2	0.2222
p.E462K	DO47255	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	0.7022
p.E462K	DO37766	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	0.7022
p.E462K	DO50286	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	0.7022
p.E462K	DO47331	SKCM	ICGC	RKENL	DEG_APCC_KENBOX_2	0.7022
p.R475Q	DO38499	STAD	ICGC	RKENL	DEG_APCC_KENBOX_2	0.0556
p.R456H	DO41752	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.R456H	DO41584	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.E456K	SIDM00336	Melanoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.E456K	ACH-000881	Skin Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.1944
p.E456K	MEL-JUSO	skin	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.G451C	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.0556
p.G451C	ACH-000929	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.0556
p.G451C	NCI-H2110	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.0556
p.R461W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.7523
p.R461W	ACH-000980	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.7523
p.R461W	NCI-H1155	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.7523
p.R466K	SIDM00864	Cervical Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.R466K	ACH-001341	Cervical Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.3056
p.R466K	DoTc2-4510	cervix	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.Q452H	SIDM00721	Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.0833
p.Q452H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.0833
p.S453G	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.1111
p.S453G	ACH-000077	Lymphoma	CCLE	RKENL	DEG_APCC_KENBOX_2	0.1111
p.S460N	SIDM01699	Chondrosarcoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.75
p.S460N	ACH-000224	Non-Cancerous	CCLE	RKENL	DEG_APCC_KENBOX_2	0.75
p.G465C	NCI-H2110	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.76
p.R475W	NCI-H1155	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.0556
p.E470K	MEL-JUSO	skin	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_APCC_KENBOX_2	90:94	RKENL	APC,CDC20,FZR1	0.9068	More...
Q9UBU7	Protein DBF4 homolog A	DEG_APCC_KENBOX_2	586:590	RKENL	APC,CDC20,FZR1	0.6044	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	461:465	RKENL	APC,CDC20,FZR1	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENL

Degron related mutations and impact score

Drug responses associated with LAD1 mutations

All proteins holding degron of RKENL