DegronMD - Q9UBU7(DBF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L543V	TCGA-06-A6S1	GBM	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1389
p.L543V	TCGA-06-A6S1	GBM	TCGA	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation rewiring degron network	0.1111
p.L543V	DO50113	GBM	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1389
p.L543V	DO50113	GBM	ICGC	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation rewiring degron network	0.1111
p.D656V	TCGA-36-2538	OV	TCGA	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.0556
p.D656V	DO28018	OV	ICGC	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.0556
p.D597G	TCGA-56-8625	LUSC	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1389
p.D597G	DO45515	LUSC	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1389
p.S538G	TCGA-64-5775	LUAD	TCGA	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation rewiring degron network	0.25
p.S538G	DO26025	LUAD	ICGC	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation rewiring degron network	0.25
p.G532D	TCGA-85-8479	LUSC	TCGA	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation altering degron motif	0.7198
p.G532D	DO45443	LUSC	ICGC	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation altering degron motif	0.7198
p.R599I	TCGA-A5-A2K5	UCEC	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.0833
p.R599I	DO41379	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.0833
p.R576Q	TCGA-AA-3984	COAD	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.0556
p.R576Q	DO9002	COAD	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.0556
p.R584Q	TCGA-AP-A056	UCEC	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.R584Q	DO233941	GACA	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.R584Q	DO43971	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.L658P	TCGA-AP-A056	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.1111
p.L658P	DO43971	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.1111
p.E556D	TCGA-AP-A0LM	UCEC	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.5647
p.E556D	DO43306	UCEC	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.5647
p.F563V	TCGA-AP-A1E0	UCEC	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1667
p.F563V	DO43154	UCEC	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1667
p.K548N	TCGA-D3-A2J8	SKCM	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.2778
p.K548N	DO37778	SKCM	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.2778
p.E595K	TCGA-DK-A1A6	BLCA	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1944
p.E595K	DO472	BLCA	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1944
p.D656H	TCGA-DK-AA6S	BLCA	TCGA	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.0556
p.D656H	DO219007	BLCA	ICGC	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.0556
p.H542D	TCGA-EE-A29S	SKCM	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1111
p.H542D	TCGA-EE-A29S	SKCM	TCGA	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation rewiring degron network	0.1389
p.H542D	DO37936	SKCM	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1111
p.H542D	DO37936	SKCM	ICGC	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation rewiring degron network	0.1389
p.R599K	TCGA-EO-A22R	UCEC	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.0833
p.R599K	DO42713	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.0833
p.S664L	TCGA-EO-A22X	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	666:670	Mutation blocking phosphorylation signal	0.7222
p.S664L	DO43907	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	666:670	Mutation blocking phosphorylation signal	0.7222
p.N25S	TCGA-F7-A624	HNSC	TCGA	NRPSLKSLK	DEG_APCC_DBOX_1	25:33	Mutation altering degron motif	0.5958
p.N25S	DO44440	HNSC	ICGC	NRPSLKSLK	DEG_APCC_DBOX_1	25:33	Mutation altering degron motif	0.5958
p.K564N	TCGA-JW-A5VL	CESC	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation substituting flanking lysine	0.25
p.K564N	DO49976	CESC	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation substituting flanking lysine	0.25
p.K564N	DO234437	ESAD	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation substituting flanking lysine	0.25
p.D597N	TCGA-ZJ-AAXB	CESC	TCGA	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1389
p.D597N	DO219753	CESC	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1389
p.E556Q	DO52582	BOCA	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.5633
p.D562Y	DO229045	LICA	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation rewiring degron network	0.1944
p.C43Y	DO229058	LICA	ICGC	NRPSLKSLK	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.0556
p.I581V	DO231091	LUSC	ICGC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1944
p.I581V	ACH-000593	Bladder Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1944
p.G532S	DO229479	SKCA	ICGC	DSGLIT	DEG_SCF_TRCP1_1	530:535	Mutation altering degron motif	0.6993
p.H552R	SIDM00640	Mesothelioma	GDSC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.7133
p.H552R	ACH-000335	Lung Cancer	CCLE	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.7133
p.H552R	MSTO-211H	pleura	COSMIC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.7133
p.I18N	SIDM01640	Acute Myeloid Leukemia	GDSC	NRPSLKSLK	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.1389
p.I18N	ACH-000602	Leukemia	CCLE	NRPSLKSLK	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.1389
p.N593K	ACH-001113	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.25
p.N593K	ACH-002156	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.25
p.N593K	LC-1-sq	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.25
p.E591K	ACH-002287	Colon/Colorectal Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.3056
p.E591K	NCI-H630	large intestine	COSMIC	RKENL	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.3056
p.A661V	SNU-407	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	666:670	Mutation rewiring degron network	0.1944
p.T553N	AU565	breast	COSMIC	PFHTPPEE	DEG_SCF_FBW7_2	550:557	Mutation altering degron motif	0.8166

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DBF4

UniProt ID: Q9UBU7

Entrez ID: 10926

Protein name: Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DBF4 in